A Role for REP Sequences in Regulating Translation

REP sequences are highly structured elements found downstream of ∼500 genes in Escherichia coli that result in extensive stem-loop structures in their mRNAs. However, their physiological role has remained elusive. Here, we show that REP sequences can down-regulate translation, but only if they are w...

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Veröffentlicht in:	Molecular cell 2015-05, Vol.58 (3), p.431-439
Hauptverfasser:	Liang, Wenxing, Rudd, Kenneth E., Deutscher, Murray P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Blotting, Northern Escherichia coli Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins - genetics gene expression regulation gene overexpression messenger RNA Models, Genetic Protein Biosynthesis Repetitive Sequences, Nucleic Acid - genetics Ribonucleoside Diphosphate Reductase - genetics Ribonucleotide Reductases - genetics ribosomes RNA helicases RNA Stability RNA, Messenger - genetics RNA, Messenger - metabolism stop codon translation (genetics)
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