Resting state functional magnetic resonance imaging reveals distinct brain activity in heavy cannabis users – a multi-voxel pattern analysis

Chronic cannabis use can cause cognitive, perceptual and personality alterations, which are believed to be associated with regional brain changes and possible changes in connectivity between functional regions. This study aims to identify the changes from resting state functional magnetic resonance...

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Veröffentlicht in:Journal of psychopharmacology (Oxford) 2014-11, Vol.28 (11), p.1030-1040
Hauptverfasser: Cheng, H, Skosnik, PD, Pruce, BJ, Brumbaugh, MS, Vollmer, JM, Fridberg, DJ, O’Donnell, BF, Hetrick, WP, Newman, SD
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container_end_page 1040
container_issue 11
container_start_page 1030
container_title Journal of psychopharmacology (Oxford)
container_volume 28
creator Cheng, H
Skosnik, PD
Pruce, BJ
Brumbaugh, MS
Vollmer, JM
Fridberg, DJ
O’Donnell, BF
Hetrick, WP
Newman, SD
description Chronic cannabis use can cause cognitive, perceptual and personality alterations, which are believed to be associated with regional brain changes and possible changes in connectivity between functional regions. This study aims to identify the changes from resting state functional magnetic resonance imaging scans. A two-level multi-voxel pattern analysis was proposed to classify male cannabis users from normal controls. The first level analysis works on a voxel basis and identifies clusters for the input of a second level analysis, which works on the functional connectivity between these regions. We found distinct clusters for male cannabis users in the middle frontal gyrus, precentral gyrus, superior frontal gyrus, posterior cingulate cortex, cerebellum and some other regions. Based on the functional connectivity of these clusters, a high overall accuracy rate of 84–88% in classification accuracy was achieved. High correlations were also found between the overall classification accuracy and Barrett Barrett Impulsiveness Scale factor scores of attention and motor. Our result suggests regional differences in the brains of male cannabis users that span from the cerebellum to the prefrontal cortex, which are associated with differences in functional connectivity.
doi_str_mv 10.1177/0269881114550354
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subjects Accuracy
Brain - drug effects
Brain - physiopathology
Brain Mapping
Case-Control Studies
Correlation analysis
Dronabinol - pharmacokinetics
Dronabinol - urine
Drug use
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Marijuana
Marijuana Abuse - physiopathology
Neural Pathways - drug effects
Neural Pathways - physiopathology
NMR
Nuclear magnetic resonance
Rest - physiology
Young Adult
title Resting state functional magnetic resonance imaging reveals distinct brain activity in heavy cannabis users – a multi-voxel pattern analysis
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