Activity of Quinolone CP-115,955 Against Bacterial and Human Type II Topoisomerases Is Mediated by Different Interactions

CP-115,955 is a quinolone with a 4-hydroxyphenyl at C7 that displays high activity against both bacterial and human type II topoisomerases. To determine the basis for quinolone cross-reactivity between bacterial and human enzymes, the activity of CP-115,955 and a series of related quinolones and qui...

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Veröffentlicht in:	Biochemistry (Easton) 2015-02, Vol.54 (5), p.1278-1286
Hauptverfasser:	Aldred, Katie J, Schwanz, Heidi A, Li, Gangqin, Williamson, Benjamin H, McPherson, Sylvia A, Turnbough, Charles L, Kerns, Robert J, Osheroff, Neil
Format:	Artikel
Sprache:	eng
Schlagworte:	antineoplastic agents Bacillus anthracis Bacillus anthracis - enzymology Bacillus anthracis - genetics Bacterial Proteins - antagonists & inhibitors Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Cell Line cross reaction DNA Topoisomerase IV - antagonists & inhibitors DNA Topoisomerase IV - chemistry DNA Topoisomerase IV - genetics DNA Topoisomerase IV - metabolism DNA Topoisomerases, Type II - chemistry DNA Topoisomerases, Type II - genetics DNA Topoisomerases, Type II - metabolism Drug Resistance, Bacterial - drug effects Drug Resistance, Bacterial - genetics enzymes Fluoroquinolones - chemistry Fluoroquinolones - pharmacology Humans in vitro culture mutants Mutation quinolones Topoisomerase II Inhibitors - chemistry Topoisomerase II Inhibitors - pharmacology
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