Phase I study of granulocyte colony-stimulating factor in patients with transitional cell carcinoma of the urothelium

Recombinant human granulocyte colony-stimulating factor (rhG-CSF) was administered at a dose of 1-60 micrograms/kg of body weight to 22 patients with transitional cell carcinoma before chemotherapy as part of a Phase I/II study. In all patients, a specific dose-dependent increase in the absolute neu...

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Veröffentlicht in:	The Journal of clinical investigation 1988-10, Vol.82 (4), p.1454-1461
Hauptverfasser:	GABRILOVE, J. L, JAKUBOWSKI, A, ALTON, K, BOONE, T, ALTROCK, B, WELTE, K, SOUZA, L, FAIN, K, GROUS, J, SCHER, H, STERNBERG, C, YAGODA, A, CLARKSON, B, BONILLA, M. A, OETTGEN, H. F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Bone Marrow - pathology Carcinoma, Transitional Cell - blood Carcinoma, Transitional Cell - drug therapy Carcinoma, Transitional Cell - pathology Colony-Forming Units Assay Colony-Stimulating Factors - adverse effects Colony-Stimulating Factors - pharmacokinetics Colony-Stimulating Factors - therapeutic use Drug Evaluation Granulocyte Colony-Stimulating Factor Hematopoietic Stem Cells - pathology Humans Leukocyte Count - drug effects Medical sciences Middle Aged Nephrology. Urinary tract diseases Neutrophils - pathology Recombinant Proteins - adverse effects Recombinant Proteins - pharmacokinetics Recombinant Proteins - therapeutic use Tumors of the urinary system Urinary tract. Prostate gland Urogenital Neoplasms - blood Urogenital Neoplasms - drug therapy Urogenital Neoplasms - pathology
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