A phase II, single-arm study of the anti-α5β1 integrin antibody volociximab as monotherapy in patients with platinum-resistant advanced epithelial ovarian or primary peritoneal cancer

Abstract Objective This phase II, multicenter, single-arm, two-stage study in platinum-resistant, advanced epithelial ovarian or primary peritoneal cancer evaluated the efficacy, safety, and tolerability of weekly single-agent volociximab. Pharmacokinetic/pharmacodynamic (PK/PD) studies were also pe...

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Veröffentlicht in:	Gynecologic oncology 2011-05, Vol.121 (2), p.273-279
Hauptverfasser:	Bell-McGuinn, Katherine M, Matthews, Carolyn M, Ho, Steffan N, Barve, Minal, Gilbert, Lucy, Penson, Richard T, Lengyel, Ernst, Palaparthy, Rameshraja, Gilder, Kye, Vassos, Artemios, McAuliffe, William, Weymer, Sara, Barton, Jeremy, Schilder, Russell J
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Antibodies, Monoclonal - adverse effects Antibodies, Monoclonal - blood Antibodies, Monoclonal - immunology Antibodies, Monoclonal - therapeutic use Biomarkers, Tumor - blood Carcinoma, Ovarian Epithelial Drug Resistance, Neoplasm Endothelial Cells - drug effects Endothelial Cells - pathology Female Hematology, Oncology and Palliative Medicine Humans Immunohistochemistry Integrin alpha5beta1 - biosynthesis Integrin alpha5beta1 - immunology Middle Aged Neoplasms, Glandular and Epithelial - blood Neoplasms, Glandular and Epithelial - drug therapy Neoplasms, Glandular and Epithelial - immunology Neoplasms, Glandular and Epithelial - pathology Neoplastic Cells, Circulating - drug effects Neoplastic Cells, Circulating - pathology Obstetrics and Gynecology Organoplatinum Compounds - pharmacology Ovarian cancer Ovarian Neoplasms - blood Ovarian Neoplasms - drug therapy Ovarian Neoplasms - immunology Ovarian Neoplasms - pathology Peritoneal Neoplasms - blood Peritoneal Neoplasms - drug therapy Peritoneal Neoplasms - immunology Peritoneal Neoplasms - pathology Platinum resistant Stem Cells - drug effects Stem Cells - pathology Volociximab α5β1 integrin
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