Experimental Hamster Infection with a Strain of Leptospira borgpetersenii Ballum Isolated from a Reservoir Mouse in New Caledonia
Leptospirosis is a neglected zoonosis caused by pathogenic Leptospira. In this study, we characterized the virulence of isolate B3-13S obtained from a wild mouse (Mus musculus) captured in New Caledonia, subsequently identified as a bacterium belonging to the L. borgpetersenii serogroup Ballum. Hams...
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| Veröffentlicht in: | The American journal of tropical medicine and hygiene 2015-05, Vol.92 (5), p.982-985 |
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| creator | Matsui, Mariko Roche, Louise Soupé-Gilbert, Marie-Estelle Roudier, Martine Moniquet, Vincent Goarant, Cyrille |
| description | Leptospirosis is a neglected zoonosis caused by pathogenic Leptospira. In this study, we characterized the virulence of isolate B3-13S obtained from a wild mouse (Mus musculus) captured in New Caledonia, subsequently identified as a bacterium belonging to the L. borgpetersenii serogroup Ballum. Hamsters were infected with an intraperitoneal injection of 2 × 10(8) bacteria, resulting in severe histopathological organ damages consistent with tissue lesions previously observed with other strains. Hamsters were also injected with 1 × 10(8) or 5 × 10(7) bacteria and animals that recovered showed renal carriage of leptospires in concentrations similar to the bacterial load quantified in mouse kidneys, with urinary shedding of bacteria up to 4 weeks postinfection. The serogroup Ballum is increasingly reported in human leptospirosis, and these results highlight the use of the B3-13S isolate for the development of models resulting in either severe acute or chronic forms of the infection, allowing for better characterization of its pathogenesis. |
| doi_str_mv | 10.4269/ajtmh.14-0462 |
| format | Article |
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In this study, we characterized the virulence of isolate B3-13S obtained from a wild mouse (Mus musculus) captured in New Caledonia, subsequently identified as a bacterium belonging to the L. borgpetersenii serogroup Ballum. Hamsters were infected with an intraperitoneal injection of 2 × 10(8) bacteria, resulting in severe histopathological organ damages consistent with tissue lesions previously observed with other strains. Hamsters were also injected with 1 × 10(8) or 5 × 10(7) bacteria and animals that recovered showed renal carriage of leptospires in concentrations similar to the bacterial load quantified in mouse kidneys, with urinary shedding of bacteria up to 4 weeks postinfection. The serogroup Ballum is increasingly reported in human leptospirosis, and these results highlight the use of the B3-13S isolate for the development of models resulting in either severe acute or chronic forms of the infection, allowing for better characterization of its pathogenesis.</description><identifier>ISSN: 0002-9637</identifier><identifier>EISSN: 1476-1645</identifier><identifier>DOI: 10.4269/ajtmh.14-0462</identifier><identifier>PMID: 25758655</identifier><language>eng</language><publisher>United States: American Society of Tropical Medicine and Hygiene</publisher><subject>Animals ; Cricetinae ; Disease Models, Animal ; Disease Reservoirs ; Human health and pathology ; Humans ; Infectious diseases ; Kidney - microbiology ; Leptospira ; Leptospira - isolation & purification ; Leptospira - pathogenicity ; Leptospira borgpetersenii ; Leptospirosis - microbiology ; Leptospirosis - transmission ; Life Sciences ; Mesocricetus ; Mice ; Mus musculus ; New Caledonia ; Rodent Diseases - microbiology ; Rodent Diseases - transmission ; Virulence ; Zoonoses</subject><ispartof>The American journal of tropical medicine and hygiene, 2015-05, Vol.92 (5), p.982-985</ispartof><rights>The American Society of Tropical Medicine and Hygiene.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>The American Society of Tropical Medicine and Hygiene 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-5fd693cc9d739de8875bab074bf15a4a7aa106b10a553088d3e291ce4483e8573</citedby><orcidid>0000-0001-8091-8521 ; 0000-0002-0690-9464</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426589/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426589/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25758655$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01163059$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Matsui, Mariko</creatorcontrib><creatorcontrib>Roche, Louise</creatorcontrib><creatorcontrib>Soupé-Gilbert, Marie-Estelle</creatorcontrib><creatorcontrib>Roudier, Martine</creatorcontrib><creatorcontrib>Moniquet, Vincent</creatorcontrib><creatorcontrib>Goarant, Cyrille</creatorcontrib><title>Experimental Hamster Infection with a Strain of Leptospira borgpetersenii Ballum Isolated from a Reservoir Mouse in New Caledonia</title><title>The American journal of tropical medicine and hygiene</title><addtitle>Am J Trop Med Hyg</addtitle><description>Leptospirosis is a neglected zoonosis caused by pathogenic Leptospira. In this study, we characterized the virulence of isolate B3-13S obtained from a wild mouse (Mus musculus) captured in New Caledonia, subsequently identified as a bacterium belonging to the L. borgpetersenii serogroup Ballum. Hamsters were infected with an intraperitoneal injection of 2 × 10(8) bacteria, resulting in severe histopathological organ damages consistent with tissue lesions previously observed with other strains. Hamsters were also injected with 1 × 10(8) or 5 × 10(7) bacteria and animals that recovered showed renal carriage of leptospires in concentrations similar to the bacterial load quantified in mouse kidneys, with urinary shedding of bacteria up to 4 weeks postinfection. The serogroup Ballum is increasingly reported in human leptospirosis, and these results highlight the use of the B3-13S isolate for the development of models resulting in either severe acute or chronic forms of the infection, allowing for better characterization of its pathogenesis.</description><subject>Animals</subject><subject>Cricetinae</subject><subject>Disease Models, Animal</subject><subject>Disease Reservoirs</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Kidney - microbiology</subject><subject>Leptospira</subject><subject>Leptospira - isolation & purification</subject><subject>Leptospira - pathogenicity</subject><subject>Leptospira borgpetersenii</subject><subject>Leptospirosis - microbiology</subject><subject>Leptospirosis - transmission</subject><subject>Life Sciences</subject><subject>Mesocricetus</subject><subject>Mice</subject><subject>Mus musculus</subject><subject>New Caledonia</subject><subject>Rodent Diseases - microbiology</subject><subject>Rodent Diseases - transmission</subject><subject>Virulence</subject><subject>Zoonoses</subject><issn>0002-9637</issn><issn>1476-1645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks1v1DAQxS0EotvCkSvyEQ4pdvyZC1JZtexKC0h8nK1JMum6SuJgZ7dw5D_Hy5YKuHCyNP7NG7_xI-QZZ-ey1NUruJmH7TmXBZO6fEAWXBpdcC3VQ7JgjJVFpYU5Iacp3TDGbcn5Y3JSKqOsVmpBflx-mzD6AccZerqCIc0Y6XrssJl9GOmtn7cU6Kc5gh9p6OgGpzmkyUegdYjXE2Y-4eg9fQN9vxvoOoUeZmxpF8OQWz9iwrgPPtJ3YZeQZpn3eEuX0GMbRg9PyKMO-oRP784z8uXq8vNyVWw-vF0vLzZFI5WcC9W1uhJNU7VGVC1aa1QNNTOy7rgCCQaAM11zBkoJZm0rsKx4g1JagVYZcUZeH3WnXT1g22THEXo3ZfMQv7sA3v19M_qtuw57J_Oela2ywMujwPafttXFxh1qjHMtmKr2PLMv7obF8HWHaXaDTw32PYyYt-C4KY02kknzf1RbxiteGpHR4og2MaQUsbt_BmfukAb3Kw2OS3dIQ-af_2n5nv79_eInSU-ywQ</recordid><startdate>20150501</startdate><enddate>20150501</enddate><creator>Matsui, Mariko</creator><creator>Roche, Louise</creator><creator>Soupé-Gilbert, Marie-Estelle</creator><creator>Roudier, Martine</creator><creator>Moniquet, Vincent</creator><creator>Goarant, Cyrille</creator><general>American Society of Tropical Medicine and Hygiene</general><general>The American Society of Tropical Medicine and Hygiene</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QL</scope><scope>C1K</scope><scope>F1W</scope><scope>H95</scope><scope>H97</scope><scope>L.G</scope><scope>M7N</scope><scope>1XC</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8091-8521</orcidid><orcidid>https://orcid.org/0000-0002-0690-9464</orcidid></search><sort><creationdate>20150501</creationdate><title>Experimental Hamster Infection with a Strain of Leptospira borgpetersenii Ballum Isolated from a Reservoir Mouse in New Caledonia</title><author>Matsui, Mariko ; Roche, Louise ; Soupé-Gilbert, Marie-Estelle ; Roudier, Martine ; Moniquet, Vincent ; Goarant, Cyrille</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-5fd693cc9d739de8875bab074bf15a4a7aa106b10a553088d3e291ce4483e8573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Cricetinae</topic><topic>Disease Models, Animal</topic><topic>Disease Reservoirs</topic><topic>Human health and pathology</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Kidney - microbiology</topic><topic>Leptospira</topic><topic>Leptospira - isolation & purification</topic><topic>Leptospira - pathogenicity</topic><topic>Leptospira borgpetersenii</topic><topic>Leptospirosis - microbiology</topic><topic>Leptospirosis - transmission</topic><topic>Life Sciences</topic><topic>Mesocricetus</topic><topic>Mice</topic><topic>Mus musculus</topic><topic>New Caledonia</topic><topic>Rodent Diseases - microbiology</topic><topic>Rodent Diseases - transmission</topic><topic>Virulence</topic><topic>Zoonoses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matsui, Mariko</creatorcontrib><creatorcontrib>Roche, Louise</creatorcontrib><creatorcontrib>Soupé-Gilbert, Marie-Estelle</creatorcontrib><creatorcontrib>Roudier, Martine</creatorcontrib><creatorcontrib>Moniquet, Vincent</creatorcontrib><creatorcontrib>Goarant, Cyrille</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The American journal of tropical medicine and hygiene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matsui, Mariko</au><au>Roche, Louise</au><au>Soupé-Gilbert, Marie-Estelle</au><au>Roudier, Martine</au><au>Moniquet, Vincent</au><au>Goarant, Cyrille</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental Hamster Infection with a Strain of Leptospira borgpetersenii Ballum Isolated from a Reservoir Mouse in New Caledonia</atitle><jtitle>The American journal of tropical medicine and hygiene</jtitle><addtitle>Am J Trop Med Hyg</addtitle><date>2015-05-01</date><risdate>2015</risdate><volume>92</volume><issue>5</issue><spage>982</spage><epage>985</epage><pages>982-985</pages><issn>0002-9637</issn><eissn>1476-1645</eissn><abstract>Leptospirosis is a neglected zoonosis caused by pathogenic Leptospira. In this study, we characterized the virulence of isolate B3-13S obtained from a wild mouse (Mus musculus) captured in New Caledonia, subsequently identified as a bacterium belonging to the L. borgpetersenii serogroup Ballum. Hamsters were infected with an intraperitoneal injection of 2 × 10(8) bacteria, resulting in severe histopathological organ damages consistent with tissue lesions previously observed with other strains. Hamsters were also injected with 1 × 10(8) or 5 × 10(7) bacteria and animals that recovered showed renal carriage of leptospires in concentrations similar to the bacterial load quantified in mouse kidneys, with urinary shedding of bacteria up to 4 weeks postinfection. 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| subjects | Animals Cricetinae Disease Models, Animal Disease Reservoirs Human health and pathology Humans Infectious diseases Kidney - microbiology Leptospira Leptospira - isolation & purification Leptospira - pathogenicity Leptospira borgpetersenii Leptospirosis - microbiology Leptospirosis - transmission Life Sciences Mesocricetus Mice Mus musculus New Caledonia Rodent Diseases - microbiology Rodent Diseases - transmission Virulence Zoonoses |
| title | Experimental Hamster Infection with a Strain of Leptospira borgpetersenii Ballum Isolated from a Reservoir Mouse in New Caledonia |
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