Quantitative evolutionary dynamics using high-resolution lineage tracking

Evolution of large asexual cell populations underlies ∼30% of deaths worldwide, including those caused by bacteria, fungi, parasites, and cancer. However, the dynamics underlying these evolutionary processes remain poorly understood because they involve many competing beneficial lineages, most of wh...

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Veröffentlicht in:	Nature (London) 2015-03, Vol.519 (7542), p.181-186
Hauptverfasser:	Levy, Sasha F., Blundell, Jamie R., Venkataram, Sandeep, Petrov, Dmitri A., Fisher, Daniel S., Sherlock, Gavin
Format:	Artikel
Sprache:	eng
Schlagworte:	45/23 45/77 631/181/2468 631/181/2475 631/208/212/2304 631/208/737 Biomedical research Cell Lineage - genetics Cell Tracking - methods Deoxyribonucleic acid DNA DNA Barcoding, Taxonomic - methods Evolution, Molecular Gene expression Gene mutations Genetic Fitness - genetics Genomes Humanities and Social Sciences Identification and classification Medical research Medicine, Experimental Methods multidisciplinary Mutagenesis - genetics Mutation Mutation Rate Parasites Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - genetics Science Time Factors Yeast
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