Effect of bone marrow transplantation on enzyme levels and clinical course in the neurologically affected twitcher mouse

The effect of allogeneic bone marrow transplantation (BMT) was investigated in the neurologically affected twitcher mouse, a model for human Krabbe's disease. Twitcher mice have a hereditary deficiency of the lysosomal enzyme galactosylceramidase, which causes growth delay, tremor, and paralysi...

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Veröffentlicht in:	The Journal of clinical investigation 1988-06, Vol.81 (6), p.1790-1794
Hauptverfasser:	HOOGERBRUGGE, P. M, POORTHUIS, B. J. H. M, ROMME, A. E, VAN DE KAMP, J. J. P, WAGEMAKER, G, VAN BEKKUM, D. W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Bone Marrow - enzymology Bone Marrow Transplantation Central Nervous System - enzymology Disease Models, Animal Female Galactosidases - deficiency Galactosylceramidase - biosynthesis Galactosylceramidase - deficiency Kidney - enzymology Leukodystrophy, Globoid Cell - enzymology Leukodystrophy, Globoid Cell - therapy Liver - enzymology Lung - enzymology Male Medical sciences Mice Mice, Inbred C57BL Mice, Neurologic Mutants Myocardium - enzymology Neurology Spleen - enzymology
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