3′-Functionalized Adamantyl Cannabinoid Receptor Probes

The aliphatic side chain plays a pivotal role in determining the cannabinergic potency of tricyclic classical cannabinoids, and we have previously shown that this chain could be substituted successfully by adamantyl or other polycyclic groups. In an effort to explore the pharmacophoric features of t...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of medicinal chemistry 2015-04, Vol.58 (7), p.3104-3116
Hauptverfasser:	Ogawa, Go, Tius, Marcus A, Zhou, Han, Nikas, Spyros P, Halikhedkar, Aneetha, Mallipeddi, Srikrishnan, Makriyannis, Alexandros
Format:	Artikel
Sprache:	eng
Schlagworte:	Adamantane - analogs & derivatives Adamantane - chemistry Animals Cannabinoids - chemistry Cell Membrane - metabolism Chemistry Techniques, Synthetic HEK293 Cells Humans Molecular Conformation Molecular Probe Techniques Molecular Probes - chemistry Molecular Probes - metabolism Radioligand Assay Rats Receptor, Cannabinoid, CB1 - metabolism Receptor, Cannabinoid, CB2 - metabolism Receptors, Cannabinoid - metabolism Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!