Estrogen receptor beta impacts hormone-induced alternative mRNA splicing in breast cancer cells

Estrogens play an important role in breast cancer (BC) development and progression; when the two isoforms of the estrogen receptor (ERα and ERβ) are co-expressed each of them mediate specific effects of these hormones in BC cells. ERβ has been suggested to exert an antagonist role toward the oncogen...

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Veröffentlicht in:	BMC genomics 2015-05, Vol.16 (1), p.367-367, Article 367
Hauptverfasser:	Dago, Dougba Noel, Scafoglio, Claudio, Rinaldi, Antonio, Memoli, Domenico, Giurato, Giorgio, Nassa, Giovanni, Ravo, Maria, Rizzo, Francesca, Tarallo, Roberta, Weisz, Alessandro
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing - drug effects Analysis Breast Neoplasms - pathology Estradiol Estradiol - pharmacology Estrogen Receptor alpha - metabolism Estrogen Receptor beta - deficiency Estrogen Receptor beta - metabolism Estrogens - pharmacology Genetic transcription High-Throughput Nucleotide Sequencing Humans MCF-7 Cells Physiological aspects Promoter Regions, Genetic - drug effects Promoter Regions, Genetic - genetics RNA sequencing RNA, Messenger - genetics Sequence Analysis, RNA
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