Tadalafil Integrates Nitric Oxide-Hydrogen Sulfide Signaling to Inhibit High Glucose-induced Matrix Protein Synthesis in Podocytes

Diabetes-induced kidney cell injury involves an increase in matrix protein expression that is only partly alleviated by current treatment, prompting a search for new modalities. We have previously shown that hydrogen sulfide (H2S) inhibits high glucose-induced protein synthesis in kidney podocytes....

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Veröffentlicht in:	The Journal of biological chemistry 2015-05, Vol.290 (19), p.12014-12026
Hauptverfasser:	Lee, Hak Joo, Feliers, Denis, Mariappan, Meenalakshmi M., Sataranatarajan, Kavithalakshmi, Choudhury, Goutam Ghosh, Gorin, Yves, Kasinath, Balakuntalam S.
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-activated kinase (AMPK) AMP-Activated Protein Kinases - metabolism Animals Calcium - chemistry Carbolines - chemistry diabetes Diabetic Nephropathies - drug therapy Diabetic Nephropathies - metabolism Extracellular Matrix - metabolism fibrosis Gene Expression Regulation Glucose - chemistry Glycobiology and Extracellular Matrices Hydrogen Sulfide - chemistry kidney Kidney - cytology mammalian target of rapamycin (mTOR) Mechanistic Target of Rapamycin Complex 1 Mice Multiprotein Complexes - metabolism Nitric Oxide - chemistry Nitric Oxide Synthase Type II - antagonists & inhibitors Phosphodiesterase 5 Inhibitors - chemistry Phosphorylation Podocytes - cytology Podocytes - metabolism Polyribosomes - metabolism Rats Signal Transduction Tadalafil TOR Serine-Threonine Kinases - metabolism
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