Primary Merkel Cell Carcinoma of the Submandibular Gland: When CK20 Status Complicates the Diagnosis
Merkel cell carcinoma is a neuroendocrine tumor that occurs predominantly on the sun-exposed skin, with rare cases in the extracutaneous sites. It represents one of the extremely rare malignant neuroendocrine tumors of the salivary glands. We report a case of primary Merkel cell carcinoma of the rig...
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| Veröffentlicht in: | Head & neck pathology (Totowa, N.J.) N.J.), 2015-06, Vol.9 (2), p.309-314 |
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| creator | Lombardi, Davide Accorona, Remo Ungari, Marco Melocchi, Laura Bell, Diana Nicolai, Piero |
| description | Merkel cell carcinoma is a neuroendocrine tumor that occurs predominantly on the sun-exposed skin, with rare cases in the extracutaneous sites. It represents one of the extremely rare malignant neuroendocrine tumors of the salivary glands. We report a case of primary Merkel cell carcinoma of the right submandibular gland. The preoperative diagnosis was doubtful and the definitive histological diagnosis proved to be very difficult considering the extreme rarity of this tumor. The intraoperative evaluation of the macroscopic characteristics of the lesion led to an elective lymph node dissection. The extreme aggressiveness of the disease has resulted in the necessity of a new post-operative staging and in a multimodal treatment. This is the first primary submandibular gland Merkel cell carcinoma described in the literature. Differential diagnosis may be challenging and proper hematoxylin-eosin staining and immunohistochemical studies are mandatory. |
| doi_str_mv | 10.1007/s12105-014-0573-1 |
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It represents one of the extremely rare malignant neuroendocrine tumors of the salivary glands. We report a case of primary Merkel cell carcinoma of the right submandibular gland. The preoperative diagnosis was doubtful and the definitive histological diagnosis proved to be very difficult considering the extreme rarity of this tumor. The intraoperative evaluation of the macroscopic characteristics of the lesion led to an elective lymph node dissection. The extreme aggressiveness of the disease has resulted in the necessity of a new post-operative staging and in a multimodal treatment. This is the first primary submandibular gland Merkel cell carcinoma described in the literature. Differential diagnosis may be challenging and proper hematoxylin-eosin staining and immunohistochemical studies are mandatory.</description><identifier>ISSN: 1936-055X</identifier><identifier>EISSN: 1936-0568</identifier><identifier>DOI: 10.1007/s12105-014-0573-1</identifier><identifier>PMID: 25314950</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Aged ; Biomarkers, Tumor - metabolism ; Carcinoma, Merkel Cell - diagnosis ; Carcinoma, Merkel Cell - metabolism ; Carcinoma, Merkel Cell - pathology ; Case Report ; Combined Modality Therapy ; Dentistry ; Diagnosis, Differential ; Female ; Humans ; Immunohistochemistry ; Keratin-20 - metabolism ; Magnetic Resonance Imaging ; Medicine ; Medicine & Public Health ; Neuroendocrine Tumors - diagnosis ; Neuroendocrine Tumors - metabolism ; Neuroendocrine Tumors - pathology ; Oral and Maxillofacial Surgery ; Otorhinolaryngology ; Pathology ; Submandibular Gland Neoplasms - diagnosis ; Submandibular Gland Neoplasms - metabolism ; Submandibular Gland Neoplasms - pathology ; Treatment Outcome</subject><ispartof>Head & neck pathology (Totowa, N.J.), 2015-06, Vol.9 (2), p.309-314</ispartof><rights>Springer Science+Business Media New York 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-a3e15d3bacd2a46a123d4c53531691fee73a9642d99797c4072b195516cd1e933</citedby><cites>FETCH-LOGICAL-c508t-a3e15d3bacd2a46a123d4c53531691fee73a9642d99797c4072b195516cd1e933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424209/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424209/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,41486,42555,51317,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25314950$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lombardi, Davide</creatorcontrib><creatorcontrib>Accorona, Remo</creatorcontrib><creatorcontrib>Ungari, Marco</creatorcontrib><creatorcontrib>Melocchi, Laura</creatorcontrib><creatorcontrib>Bell, Diana</creatorcontrib><creatorcontrib>Nicolai, Piero</creatorcontrib><title>Primary Merkel Cell Carcinoma of the Submandibular Gland: When CK20 Status Complicates the Diagnosis</title><title>Head & neck pathology (Totowa, N.J.)</title><addtitle>Head and Neck Pathol</addtitle><addtitle>Head Neck Pathol</addtitle><description>Merkel cell carcinoma is a neuroendocrine tumor that occurs predominantly on the sun-exposed skin, with rare cases in the extracutaneous sites. It represents one of the extremely rare malignant neuroendocrine tumors of the salivary glands. We report a case of primary Merkel cell carcinoma of the right submandibular gland. The preoperative diagnosis was doubtful and the definitive histological diagnosis proved to be very difficult considering the extreme rarity of this tumor. The intraoperative evaluation of the macroscopic characteristics of the lesion led to an elective lymph node dissection. The extreme aggressiveness of the disease has resulted in the necessity of a new post-operative staging and in a multimodal treatment. This is the first primary submandibular gland Merkel cell carcinoma described in the literature. Differential diagnosis may be challenging and proper hematoxylin-eosin staining and immunohistochemical studies are mandatory.</description><subject>Aged</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Carcinoma, Merkel Cell - diagnosis</subject><subject>Carcinoma, Merkel Cell - metabolism</subject><subject>Carcinoma, Merkel Cell - pathology</subject><subject>Case Report</subject><subject>Combined Modality Therapy</subject><subject>Dentistry</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Keratin-20 - metabolism</subject><subject>Magnetic Resonance Imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neuroendocrine Tumors - diagnosis</subject><subject>Neuroendocrine Tumors - metabolism</subject><subject>Neuroendocrine Tumors - pathology</subject><subject>Oral and Maxillofacial Surgery</subject><subject>Otorhinolaryngology</subject><subject>Pathology</subject><subject>Submandibular Gland Neoplasms - diagnosis</subject><subject>Submandibular Gland Neoplasms - metabolism</subject><subject>Submandibular Gland Neoplasms - pathology</subject><subject>Treatment Outcome</subject><issn>1936-055X</issn><issn>1936-0568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UU1v1DAQtRAV_YAfwAX5yCXF448k5oCEAhTUIpAKgpvldWZ3XRJ7sZNK_Hu8pF3BhYs91rz35nkeIU-BnQNjzYsMHJiqGMiKqUZU8ICcgBZ1edXtw0Otvh-T05xvGKtZI9kjcsyVAKkVOyH95-RHm37Rj5h-4EA7HMphk_MhjpbGNZ22SK_n1WhD71fzYBO9GEr9kn7bYqDdJWf0erLTnGkXx93gnZ0w_2G98XYTYvb5MTla2yHjk7v7jHx99_ZL9766-nTxoXt9VTnF2qmyAkH1YmVdz62sLXDRS6dEMVtrWCM2wupa8l7rRjdOsoavQCsFtesBtRBn5NWiuyt-sXcYpmQHs1u-aKL15t9O8FuzibdGSi4500Xg-Z1Aij9nzJMZfXZlJTZgnLOBumXQtg3sobBAXYo5J1wfxgAz-3TMko4p6Zh9OgYK59nf_g6M-zgKgC-AXFphg8ncxDmFsrP_qP4GaXqafg</recordid><startdate>20150601</startdate><enddate>20150601</enddate><creator>Lombardi, Davide</creator><creator>Accorona, Remo</creator><creator>Ungari, Marco</creator><creator>Melocchi, Laura</creator><creator>Bell, Diana</creator><creator>Nicolai, Piero</creator><general>Springer US</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150601</creationdate><title>Primary Merkel Cell Carcinoma of the Submandibular Gland: When CK20 Status Complicates the Diagnosis</title><author>Lombardi, Davide ; Accorona, Remo ; Ungari, Marco ; Melocchi, Laura ; Bell, Diana ; Nicolai, Piero</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-a3e15d3bacd2a46a123d4c53531691fee73a9642d99797c4072b195516cd1e933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Carcinoma, Merkel Cell - diagnosis</topic><topic>Carcinoma, Merkel Cell - metabolism</topic><topic>Carcinoma, Merkel Cell - pathology</topic><topic>Case Report</topic><topic>Combined Modality Therapy</topic><topic>Dentistry</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Keratin-20 - metabolism</topic><topic>Magnetic Resonance Imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neuroendocrine Tumors - diagnosis</topic><topic>Neuroendocrine Tumors - metabolism</topic><topic>Neuroendocrine Tumors - pathology</topic><topic>Oral and Maxillofacial Surgery</topic><topic>Otorhinolaryngology</topic><topic>Pathology</topic><topic>Submandibular Gland Neoplasms - diagnosis</topic><topic>Submandibular Gland Neoplasms - metabolism</topic><topic>Submandibular Gland Neoplasms - pathology</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lombardi, Davide</creatorcontrib><creatorcontrib>Accorona, Remo</creatorcontrib><creatorcontrib>Ungari, Marco</creatorcontrib><creatorcontrib>Melocchi, Laura</creatorcontrib><creatorcontrib>Bell, Diana</creatorcontrib><creatorcontrib>Nicolai, Piero</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Head & neck pathology (Totowa, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lombardi, Davide</au><au>Accorona, Remo</au><au>Ungari, Marco</au><au>Melocchi, Laura</au><au>Bell, Diana</au><au>Nicolai, Piero</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Primary Merkel Cell Carcinoma of the Submandibular Gland: When CK20 Status Complicates the Diagnosis</atitle><jtitle>Head & neck pathology (Totowa, N.J.)</jtitle><stitle>Head and Neck Pathol</stitle><addtitle>Head Neck Pathol</addtitle><date>2015-06-01</date><risdate>2015</risdate><volume>9</volume><issue>2</issue><spage>309</spage><epage>314</epage><pages>309-314</pages><issn>1936-055X</issn><eissn>1936-0568</eissn><abstract>Merkel cell carcinoma is a neuroendocrine tumor that occurs predominantly on the sun-exposed skin, with rare cases in the extracutaneous sites. It represents one of the extremely rare malignant neuroendocrine tumors of the salivary glands. We report a case of primary Merkel cell carcinoma of the right submandibular gland. The preoperative diagnosis was doubtful and the definitive histological diagnosis proved to be very difficult considering the extreme rarity of this tumor. The intraoperative evaluation of the macroscopic characteristics of the lesion led to an elective lymph node dissection. The extreme aggressiveness of the disease has resulted in the necessity of a new post-operative staging and in a multimodal treatment. This is the first primary submandibular gland Merkel cell carcinoma described in the literature. Differential diagnosis may be challenging and proper hematoxylin-eosin staining and immunohistochemical studies are mandatory.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>25314950</pmid><doi>10.1007/s12105-014-0573-1</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Biomarkers, Tumor - metabolism Carcinoma, Merkel Cell - diagnosis Carcinoma, Merkel Cell - metabolism Carcinoma, Merkel Cell - pathology Case Report Combined Modality Therapy Dentistry Diagnosis, Differential Female Humans Immunohistochemistry Keratin-20 - metabolism Magnetic Resonance Imaging Medicine Medicine & Public Health Neuroendocrine Tumors - diagnosis Neuroendocrine Tumors - metabolism Neuroendocrine Tumors - pathology Oral and Maxillofacial Surgery Otorhinolaryngology Pathology Submandibular Gland Neoplasms - diagnosis Submandibular Gland Neoplasms - metabolism Submandibular Gland Neoplasms - pathology Treatment Outcome |
| title | Primary Merkel Cell Carcinoma of the Submandibular Gland: When CK20 Status Complicates the Diagnosis |
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