Mesenchymal Wnt signaling promotes formation of sternum and thoracic body wall

Midline defects account for approximately 5% of congenital abnormalities observed at birth. However, the molecular mechanisms underlying the formation of the ventral body wall are not well understood. Recent studies linked mutations in Porcupine—an O-acetyl transferase mediating Wnt ligand acylation...

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Veröffentlicht in:	Developmental biology 2015-05, Vol.401 (2), p.264-275
Hauptverfasser:	Snowball, John, Ambalavanan, Manoj, Cornett, Bridget, Lang, Richard, Whitsett, Jeffrey, Sinner, Debora
Format:	Artikel
Sprache:	eng
Schlagworte:	acetyltransferases Acyltransferases animal models Animals Axin Protein - genetics beta catenin beta Catenin - genetics cell movement Cell Movement - genetics Cell Proliferation Cells, Cultured chest congenital abnormalities ectopia cordis Ectopia Cordis - genetics embryo (animal) forelimbs Gene Expression Regulation, Developmental heart in vitro studies integument Intracellular Signaling Peptides and Proteins - genetics ligands Low Density Lipoprotein Receptor-Related Protein-5 - genetics Low Density Lipoprotein Receptor-Related Protein-6 - genetics Membrane Proteins - genetics Mesoderm - embryology Mesoderm - metabolism Mice Mice, Knockout Midline defects mutation Neural Tube Defects - genetics pathogenesis Pentalogy of Cantrell phenotype receptors Receptors, G-Protein-Coupled - genetics ribs secretion Sternum Sternum - embryology Thoracic Cavity - embryology Wls Wnt Proteins - genetics Wnt Signaling Pathway - genetics
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