Therapeutic plasma exchange may improve hemodynamics and organ failure among children with sepsis-induced multiple organ dysfunction syndrome receiving extracorporeal life support
To determine the effect of therapeutic plasma exchange on hemodynamics, organ failure, and survival in children with multiple organ dysfunction syndrome due to sepsis requiring extracorporeal life support. A retrospective analysis. A PICU in an academic children's hospital. Fourteen consecutive...
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| Veröffentlicht in: | Pediatric critical care medicine 2015-05, Vol.16 (4), p.366-374 |
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| creator | Kawai, Yu Cornell, Timothy T Cooley, Elaine G Beckman, Craig N Baldridge, Paula K Mottes, Theresa A Luckritz, Kera E Plomaritas, Kathryn S Meade, J Michael Odetola, Folafoluwa O Han, Yong Y Blatt, Neal B Annich, Gail M |
| description | To determine the effect of therapeutic plasma exchange on hemodynamics, organ failure, and survival in children with multiple organ dysfunction syndrome due to sepsis requiring extracorporeal life support.
A retrospective analysis.
A PICU in an academic children's hospital.
Fourteen consecutive children with sepsis and multiple organ dysfunction syndrome who received therapeutic plasma exchange while on extracorporeal life support from 2005 to 2013.
Median of three cycles of therapeutic plasma exchange with median of 1.0 times the estimated plasma volume per exchange.
Organ Failure Index and Vasoactive-Inotropic Score were measured before and after therapeutic plasma exchange use. PICU survival in our cohort was 71.4%. Organ Failure Index decreased in patients following therapeutic plasma exchange (mean ± SD: pre, 4.1 ± 0.7 vs post, 2.9 ± 0.9; p = 0.0004). Patients showed improved Vasoactive-Inotropic Score following therapeutic plasma exchange (median [25th-75th]: pre, 24.5 [13.0-69.8] vs post, 5.0 [1.5-7.0]; p = 0.0002). Among all patients, the change in Organ Failure Index was greater for early therapeutic plasma exchange use than late use (early, -1.7 ± 1.2 vs late, -0.9 ± 0.6; p = 0.14), similar to the change in Vasoactive-Inotropic Score (early, -67.5 [28.0-171.2] vs late, -12.0 [7.2-18.5]; p = 0.02). Among survivors, the change in Organ Failure Index was greater among early therapeutic plasma exchange use than late use (early, -2.3 ± 1.0 vs late, -0.8 ± 0.8; p = 0.03), as was the change in Vasoactive-Inotropic Score (early, -42.0 [16.0-76.3] vs late, -12.0 [5.3-29.0]; p = 0.17). The mean duration of extracorporeal life support after therapeutic plasma exchange according to timing of therapeutic plasma exchange was not statistically different among all patients or among survivors.
The use of therapeutic plasma exchange in children on extracorporeal life support with sepsis-induced multiple organ dysfunction syndrome is associated with organ failure recovery and improved hemodynamic status. Initiating therapeutic plasma exchange early in the hospital course was associated with greater improvement in organ dysfunction and decreased requirement for vasoactive and/or inotropic agents. |
| doi_str_mv | 10.1097/PCC.0000000000000351 |
| format | Article |
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A retrospective analysis.
A PICU in an academic children's hospital.
Fourteen consecutive children with sepsis and multiple organ dysfunction syndrome who received therapeutic plasma exchange while on extracorporeal life support from 2005 to 2013.
Median of three cycles of therapeutic plasma exchange with median of 1.0 times the estimated plasma volume per exchange.
Organ Failure Index and Vasoactive-Inotropic Score were measured before and after therapeutic plasma exchange use. PICU survival in our cohort was 71.4%. Organ Failure Index decreased in patients following therapeutic plasma exchange (mean ± SD: pre, 4.1 ± 0.7 vs post, 2.9 ± 0.9; p = 0.0004). Patients showed improved Vasoactive-Inotropic Score following therapeutic plasma exchange (median [25th-75th]: pre, 24.5 [13.0-69.8] vs post, 5.0 [1.5-7.0]; p = 0.0002). Among all patients, the change in Organ Failure Index was greater for early therapeutic plasma exchange use than late use (early, -1.7 ± 1.2 vs late, -0.9 ± 0.6; p = 0.14), similar to the change in Vasoactive-Inotropic Score (early, -67.5 [28.0-171.2] vs late, -12.0 [7.2-18.5]; p = 0.02). Among survivors, the change in Organ Failure Index was greater among early therapeutic plasma exchange use than late use (early, -2.3 ± 1.0 vs late, -0.8 ± 0.8; p = 0.03), as was the change in Vasoactive-Inotropic Score (early, -42.0 [16.0-76.3] vs late, -12.0 [5.3-29.0]; p = 0.17). The mean duration of extracorporeal life support after therapeutic plasma exchange according to timing of therapeutic plasma exchange was not statistically different among all patients or among survivors.
The use of therapeutic plasma exchange in children on extracorporeal life support with sepsis-induced multiple organ dysfunction syndrome is associated with organ failure recovery and improved hemodynamic status. Initiating therapeutic plasma exchange early in the hospital course was associated with greater improvement in organ dysfunction and decreased requirement for vasoactive and/or inotropic agents.</description><identifier>ISSN: 1529-7535</identifier><identifier>DOI: 10.1097/PCC.0000000000000351</identifier><identifier>PMID: 25599148</identifier><language>eng</language><publisher>United States</publisher><subject>Adolescent ; Child ; Child, Preschool ; Combined Modality Therapy - methods ; Female ; Hemodynamics ; Humans ; Infant ; Length of Stay - statistics & numerical data ; Life Support Systems - statistics & numerical data ; Life Support Systems - utilization ; Male ; Multiple Organ Failure - etiology ; Multiple Organ Failure - physiopathology ; Multiple Organ Failure - therapy ; Plasma Exchange - statistics & numerical data ; Plasma Exchange - utilization ; Retrospective Studies ; Sepsis - complications ; Severity of Illness Index ; Survival Rate ; Treatment Outcome</subject><ispartof>Pediatric critical care medicine, 2015-05, Vol.16 (4), p.366-374</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-cbae1be882cf44e11405d3eaeb1245a5df02c79d0baed2931d3832101807e60a3</citedby><cites>FETCH-LOGICAL-c478t-cbae1be882cf44e11405d3eaeb1245a5df02c79d0baed2931d3832101807e60a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,781,785,886,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25599148$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kawai, Yu</creatorcontrib><creatorcontrib>Cornell, Timothy T</creatorcontrib><creatorcontrib>Cooley, Elaine G</creatorcontrib><creatorcontrib>Beckman, Craig N</creatorcontrib><creatorcontrib>Baldridge, Paula K</creatorcontrib><creatorcontrib>Mottes, Theresa A</creatorcontrib><creatorcontrib>Luckritz, Kera E</creatorcontrib><creatorcontrib>Plomaritas, Kathryn S</creatorcontrib><creatorcontrib>Meade, J Michael</creatorcontrib><creatorcontrib>Odetola, Folafoluwa O</creatorcontrib><creatorcontrib>Han, Yong Y</creatorcontrib><creatorcontrib>Blatt, Neal B</creatorcontrib><creatorcontrib>Annich, Gail M</creatorcontrib><title>Therapeutic plasma exchange may improve hemodynamics and organ failure among children with sepsis-induced multiple organ dysfunction syndrome receiving extracorporeal life support</title><title>Pediatric critical care medicine</title><addtitle>Pediatr Crit Care Med</addtitle><description>To determine the effect of therapeutic plasma exchange on hemodynamics, organ failure, and survival in children with multiple organ dysfunction syndrome due to sepsis requiring extracorporeal life support.
A retrospective analysis.
A PICU in an academic children's hospital.
Fourteen consecutive children with sepsis and multiple organ dysfunction syndrome who received therapeutic plasma exchange while on extracorporeal life support from 2005 to 2013.
Median of three cycles of therapeutic plasma exchange with median of 1.0 times the estimated plasma volume per exchange.
Organ Failure Index and Vasoactive-Inotropic Score were measured before and after therapeutic plasma exchange use. PICU survival in our cohort was 71.4%. Organ Failure Index decreased in patients following therapeutic plasma exchange (mean ± SD: pre, 4.1 ± 0.7 vs post, 2.9 ± 0.9; p = 0.0004). Patients showed improved Vasoactive-Inotropic Score following therapeutic plasma exchange (median [25th-75th]: pre, 24.5 [13.0-69.8] vs post, 5.0 [1.5-7.0]; p = 0.0002). Among all patients, the change in Organ Failure Index was greater for early therapeutic plasma exchange use than late use (early, -1.7 ± 1.2 vs late, -0.9 ± 0.6; p = 0.14), similar to the change in Vasoactive-Inotropic Score (early, -67.5 [28.0-171.2] vs late, -12.0 [7.2-18.5]; p = 0.02). Among survivors, the change in Organ Failure Index was greater among early therapeutic plasma exchange use than late use (early, -2.3 ± 1.0 vs late, -0.8 ± 0.8; p = 0.03), as was the change in Vasoactive-Inotropic Score (early, -42.0 [16.0-76.3] vs late, -12.0 [5.3-29.0]; p = 0.17). The mean duration of extracorporeal life support after therapeutic plasma exchange according to timing of therapeutic plasma exchange was not statistically different among all patients or among survivors.
The use of therapeutic plasma exchange in children on extracorporeal life support with sepsis-induced multiple organ dysfunction syndrome is associated with organ failure recovery and improved hemodynamic status. Initiating therapeutic plasma exchange early in the hospital course was associated with greater improvement in organ dysfunction and decreased requirement for vasoactive and/or inotropic agents.</description><subject>Adolescent</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Combined Modality Therapy - methods</subject><subject>Female</subject><subject>Hemodynamics</subject><subject>Humans</subject><subject>Infant</subject><subject>Length of Stay - statistics & numerical data</subject><subject>Life Support Systems - statistics & numerical data</subject><subject>Life Support Systems - utilization</subject><subject>Male</subject><subject>Multiple Organ Failure - etiology</subject><subject>Multiple Organ Failure - physiopathology</subject><subject>Multiple Organ Failure - therapy</subject><subject>Plasma Exchange - statistics & numerical data</subject><subject>Plasma Exchange - utilization</subject><subject>Retrospective Studies</subject><subject>Sepsis - complications</subject><subject>Severity of Illness Index</subject><subject>Survival Rate</subject><subject>Treatment Outcome</subject><issn>1529-7535</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdUctu1TAQ9QJES-EPEPKSTVo7sfPYIKErCkiVYFHW1lx7cmPkR7CTS_Nd_CBGva0KsxmN5rykQ8gbzi45G7qrb7vdJXs6jeTPyDmX9VB1spFn5GXOPxjjQyu6F-SslnIYuOjPye_bCRPMuC5W09lB9kDxTk8QDkg9bNT6OcUj0gl9NFsAb3WmEAyN6QCBjmDdmpCCj-FA9WSdSRjoL7tMNOOcba5sMKtGQ_3qFjs7PDHNlsc16MXGQPMWTIoeaUKN9miLFN4tCXRMc0wIjjo7Is3rXM7lFXk-gsv4-rQvyPfrj7e7z9XN109fdh9uKi26fqn0HpDvse9rPQqBnAsmTYOAe14LCdKMrNbdYFjBmXpouGn6puaM96zDlkFzQd7f687r3qPRGEokp-ZkPaRNRbDq30-wkzrEoxKiLl5dEXh3Ekjx54p5Ud5mjc5BwLhmxdu-uPG2FQUq7qE6xZwTjo82nKm_HavSsfq_40J7-zTiI-mh4OYPFW6sCw</recordid><startdate>20150501</startdate><enddate>20150501</enddate><creator>Kawai, Yu</creator><creator>Cornell, Timothy T</creator><creator>Cooley, Elaine G</creator><creator>Beckman, Craig N</creator><creator>Baldridge, Paula K</creator><creator>Mottes, Theresa A</creator><creator>Luckritz, Kera E</creator><creator>Plomaritas, Kathryn S</creator><creator>Meade, J Michael</creator><creator>Odetola, Folafoluwa O</creator><creator>Han, Yong Y</creator><creator>Blatt, Neal B</creator><creator>Annich, Gail M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150501</creationdate><title>Therapeutic plasma exchange may improve hemodynamics and organ failure among children with sepsis-induced multiple organ dysfunction syndrome receiving extracorporeal life support</title><author>Kawai, Yu ; Cornell, Timothy T ; Cooley, Elaine G ; Beckman, Craig N ; Baldridge, Paula K ; Mottes, Theresa A ; Luckritz, Kera E ; Plomaritas, Kathryn S ; Meade, J Michael ; Odetola, Folafoluwa O ; Han, Yong Y ; Blatt, Neal B ; Annich, Gail M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-cbae1be882cf44e11405d3eaeb1245a5df02c79d0baed2931d3832101807e60a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Combined Modality Therapy - methods</topic><topic>Female</topic><topic>Hemodynamics</topic><topic>Humans</topic><topic>Infant</topic><topic>Length of Stay - statistics & numerical data</topic><topic>Life Support Systems - statistics & numerical data</topic><topic>Life Support Systems - utilization</topic><topic>Male</topic><topic>Multiple Organ Failure - etiology</topic><topic>Multiple Organ Failure - physiopathology</topic><topic>Multiple Organ Failure - therapy</topic><topic>Plasma Exchange - statistics & numerical data</topic><topic>Plasma Exchange - utilization</topic><topic>Retrospective Studies</topic><topic>Sepsis - complications</topic><topic>Severity of Illness Index</topic><topic>Survival Rate</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kawai, Yu</creatorcontrib><creatorcontrib>Cornell, Timothy T</creatorcontrib><creatorcontrib>Cooley, Elaine G</creatorcontrib><creatorcontrib>Beckman, Craig N</creatorcontrib><creatorcontrib>Baldridge, Paula K</creatorcontrib><creatorcontrib>Mottes, Theresa A</creatorcontrib><creatorcontrib>Luckritz, Kera E</creatorcontrib><creatorcontrib>Plomaritas, Kathryn S</creatorcontrib><creatorcontrib>Meade, J Michael</creatorcontrib><creatorcontrib>Odetola, Folafoluwa O</creatorcontrib><creatorcontrib>Han, Yong Y</creatorcontrib><creatorcontrib>Blatt, Neal B</creatorcontrib><creatorcontrib>Annich, Gail M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pediatric critical care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawai, Yu</au><au>Cornell, Timothy T</au><au>Cooley, Elaine G</au><au>Beckman, Craig N</au><au>Baldridge, Paula K</au><au>Mottes, Theresa A</au><au>Luckritz, Kera E</au><au>Plomaritas, Kathryn S</au><au>Meade, J Michael</au><au>Odetola, Folafoluwa O</au><au>Han, Yong Y</au><au>Blatt, Neal B</au><au>Annich, Gail M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Therapeutic plasma exchange may improve hemodynamics and organ failure among children with sepsis-induced multiple organ dysfunction syndrome receiving extracorporeal life support</atitle><jtitle>Pediatric critical care medicine</jtitle><addtitle>Pediatr Crit Care Med</addtitle><date>2015-05-01</date><risdate>2015</risdate><volume>16</volume><issue>4</issue><spage>366</spage><epage>374</epage><pages>366-374</pages><issn>1529-7535</issn><abstract>To determine the effect of therapeutic plasma exchange on hemodynamics, organ failure, and survival in children with multiple organ dysfunction syndrome due to sepsis requiring extracorporeal life support.
A retrospective analysis.
A PICU in an academic children's hospital.
Fourteen consecutive children with sepsis and multiple organ dysfunction syndrome who received therapeutic plasma exchange while on extracorporeal life support from 2005 to 2013.
Median of three cycles of therapeutic plasma exchange with median of 1.0 times the estimated plasma volume per exchange.
Organ Failure Index and Vasoactive-Inotropic Score were measured before and after therapeutic plasma exchange use. PICU survival in our cohort was 71.4%. Organ Failure Index decreased in patients following therapeutic plasma exchange (mean ± SD: pre, 4.1 ± 0.7 vs post, 2.9 ± 0.9; p = 0.0004). Patients showed improved Vasoactive-Inotropic Score following therapeutic plasma exchange (median [25th-75th]: pre, 24.5 [13.0-69.8] vs post, 5.0 [1.5-7.0]; p = 0.0002). Among all patients, the change in Organ Failure Index was greater for early therapeutic plasma exchange use than late use (early, -1.7 ± 1.2 vs late, -0.9 ± 0.6; p = 0.14), similar to the change in Vasoactive-Inotropic Score (early, -67.5 [28.0-171.2] vs late, -12.0 [7.2-18.5]; p = 0.02). Among survivors, the change in Organ Failure Index was greater among early therapeutic plasma exchange use than late use (early, -2.3 ± 1.0 vs late, -0.8 ± 0.8; p = 0.03), as was the change in Vasoactive-Inotropic Score (early, -42.0 [16.0-76.3] vs late, -12.0 [5.3-29.0]; p = 0.17). The mean duration of extracorporeal life support after therapeutic plasma exchange according to timing of therapeutic plasma exchange was not statistically different among all patients or among survivors.
The use of therapeutic plasma exchange in children on extracorporeal life support with sepsis-induced multiple organ dysfunction syndrome is associated with organ failure recovery and improved hemodynamic status. Initiating therapeutic plasma exchange early in the hospital course was associated with greater improvement in organ dysfunction and decreased requirement for vasoactive and/or inotropic agents.</abstract><cop>United States</cop><pmid>25599148</pmid><doi>10.1097/PCC.0000000000000351</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Pediatric critical care medicine, 2015-05, Vol.16 (4), p.366-374 |
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| source | MEDLINE; Journals@Ovid Ovid Autoload |
| subjects | Adolescent Child Child, Preschool Combined Modality Therapy - methods Female Hemodynamics Humans Infant Length of Stay - statistics & numerical data Life Support Systems - statistics & numerical data Life Support Systems - utilization Male Multiple Organ Failure - etiology Multiple Organ Failure - physiopathology Multiple Organ Failure - therapy Plasma Exchange - statistics & numerical data Plasma Exchange - utilization Retrospective Studies Sepsis - complications Severity of Illness Index Survival Rate Treatment Outcome |
| title | Therapeutic plasma exchange may improve hemodynamics and organ failure among children with sepsis-induced multiple organ dysfunction syndrome receiving extracorporeal life support |
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