MicroRNA-221 inhibits autophagy and promotes heart failure by modulating the p27/CDK2/mTOR axis

MicroRNAs have emerged as crucial regulators of cardiac homeostasis and remodeling in various cardiovascular diseases. We previously demonstrated that miR-221 regulated cardiac hypertrophy in vitro . In the present study, we demonstrated that the cardiac-specific overexpression of miR-221 in mice ev...

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Veröffentlicht in:	Cell death and differentiation 2015-06, Vol.22 (6), p.986-999
Hauptverfasser:	Su, M, Wang, J, Wang, C, Wang, X, Dong, W, Qiu, W, Wang, Y, Zhao, X, Zou, Y, Song, L, Zhang, L, Hui, R
Format:	Artikel
Sprache:	eng
Schlagworte:	13/109 13/2 13/95 14/19 14/28 38/77 38/89 42/44 59 631/80/39/2346 64/60 96/63 Animals Apoptosis Apoptosis - genetics Apoptosis - physiology Autophagy Autophagy - genetics Autophagy - physiology Biochemistry Biomedical and Life Sciences Blotting, Western Cardiomyocytes Cardiovascular diseases Cell Biology Cell Cycle Analysis Cells, Cultured Congestive heart failure Cyclin-dependent kinase 2 Cyclin-dependent kinase inhibitor p27 Cyclin-dependent kinases Echocardiography Enzyme inhibitors Heart failure Heart Failure - genetics Heart Failure - metabolism Homeostasis Hypertrophy Kinases Life Sciences Male Mice MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism Microscopy, Electron, Transmission Microtubule-associated protein 1 miRNA Myocardium - metabolism Original Paper Phagocytosis Proliferating Cell Nuclear Antigen - genetics Proliferating Cell Nuclear Antigen - metabolism Rapamycin Rats siRNA Stem Cells TOR protein TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism Transgenic mice
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