Covert Changes in CaMKII Holoenzyme Structure Identified for Activation and Subsequent Interactions

Between 8 to 14 calcium-calmodulin (Ca2+/CaM) dependent protein kinase-II (CaMKII) subunits form a complex that modulates synaptic activity. In living cells, the autoinhibited holoenzyme is organized as catalytic-domain pairs distributed around a central oligomerization-domain core. The functional s...

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Veröffentlicht in:	Biophysical journal 2015-05, Vol.108 (9), p.2158-2170
Hauptverfasser:	Nguyen, Tuan A., Sarkar, Pabak, Veetil, Jithesh V., Davis, Kaitlin A., Puhl, Henry L., Vogel, Steven S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphatase Amino Acid Sequence Calcium Calcium - metabolism Calcium-Calmodulin-Dependent Protein Kinase Type 2 - chemistry Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism Catalysis Catalytic Domain Cell Biophysics Cells Enzymes HEK293 Cells Holoenzymes - chemistry Holoenzymes - metabolism Humans Kinases Molecular Sequence Data Protein Binding Threonine - chemistry Threonine - metabolism
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