The prolactin family hormones regulate vascular tone through NO and prostacyclin production in isolated rat aortic rings

Aim： Prolactin family hormones include growth hormone, placental lactogen and prolactin, which are able to regulate angiogenesis via NO and prostaglandins. However, their effects on vascular tone are not fully understood. The aim of this study was to evaluate the effects of prolactin family hormones...

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Veröffentlicht in:	Acta pharmacologica Sinica 2015-05, Vol.36 (5), p.572-586
Hauptverfasser:	Gonzalez, Carmen, Rosas-Hernandez, Hector, Jurado-manzano, Brenda, Ramirez-Lee, Manuel Alejandro, Salazar-Garcia, Samuel, Martinez-Cuevas, Pedro Pablo, Velarde-salcedo, Aída Jimena, Morales-Loredo, Humberto, Espinosa-Tanguma, Ricardo, Ali, Syed F, Rubio, Rafael
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - drug effects Aorta - metabolism Biomedical and Life Sciences Biomedicine Cells, Cultured Dose-Response Relationship, Drug Endothelial Cells - drug effects Endothelial Cells - metabolism eNOS Epoprostenol - metabolism Human Growth Hormone - pharmacology Immunology In Vitro Techniques Internal Medicine Male Medical Microbiology Nitric Oxide - metabolism Nitric Oxide Synthase Type III - metabolism Original original-article Pharmacology/Toxicology Phosphorylation Placental Lactogen - pharmacology Prolactin - pharmacology Rats, Wistar Receptors, Somatotropin - drug effects Receptors, Somatotropin - metabolism Serine Signal Transduction - drug effects Time Factors Vaccine Vasoconstriction - drug effects Vasoconstrictor Agents - pharmacology Vasodilation - drug effects Vasodilator Agents - pharmacology 主动脉催乳素受体前列环素张力测量生长激素受体血管生成雄性大鼠
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