The transcription factor MITF is a critical regulator of GPNMB expression in dendritic cells

Dendritic cells (DC) are the most potent antigen-presenting cells (APC) with the unique ability to activate naïve T cells and to initiate and maintain primary immune responses. Immunosuppressive and anti-inflammatory stimuli on DC such as the cytokine IL-10 suppress the activity of the transcription...

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Veröffentlicht in:	Cell communication and signaling 2015-03, Vol.13 (1), p.19, Article 19
Hauptverfasser:	Gutknecht, Michael, Geiger, Julian, Joas, Simone, Dörfel, Daniela, Salih, Helmut R, Müller, Martin R, Grünebach, Frank, Rittig, Susanne M
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Antineoplastic Agents - pharmacology Benzamides - pharmacology Cells, Cultured Computer software industry Cytokines Dendritic cells Dendritic Cells - cytology Dendritic Cells - metabolism Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Humans Imatinib Mesylate Immune response Immunotherapy Interleukin-10 - pharmacology Leukemia Membrane Glycoproteins - biosynthesis Microphthalmia-Associated Transcription Factor - metabolism Phosphatidylinositol 3-Kinases - metabolism Physiological aspects Piperazines - pharmacology Protein kinases Proto-Oncogene Proteins c-akt - metabolism Pyrimidines - pharmacology RNA T cells Tyrosine
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