Enhanced activation of dendritic cells by autologous apoptotic microvesicles in MRL/lpr mice

Systemic lupus erythematosus is associated with a persistent circulation of modified autoantigen-containing apoptotic debris that might be capable of breaking tolerance. We aimed to evaluate apoptotic microvesicles obtained from lupus or control mice for the presence of apoptosis-associated chromati...

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Veröffentlicht in:	Arthritis research & therapy 2015-04, Vol.17 (1), p.103-103, Article 103
Hauptverfasser:	Dieker, Jürgen, Hilbrands, Luuk, Thielen, Astrid, Dijkman, Henry, Berden, Jo H, van der Vlag, Johan
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Apoptosis Apoptosis - immunology Autoantigens - immunology Autoimmunity B cells Bone morphogenetic proteins Cell-Derived Microparticles - immunology Cells, Cultured Chromatin Dendritic cells Dendritic Cells - immunology Dendritic Cells - metabolism Disease Models, Animal Enzyme-Linked Immunosorbent Assay Flow Cytometry Interleukins Lupus Lupus Erythematosus, Systemic - immunology Mice Mice, Inbred BALB C Mice, Inbred MRL lpr Sensitivity and Specificity Transforming growth factors
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