Synthesis and bioactivities of silver nanoparticles capped with 5-Amino-?-resorcylic acid hydrochloride dihydrate
Conjugated and drug loaded silver nanoparticles are getting an increased attention for various biomedical applications. Nanoconjugates showed significant enhancement in biological activity in comparison to free drug molecules. In this perspective, we report the synthesis of bioactive silver capped w...
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| Veröffentlicht in: | Journal of nanobiotechnology 2014-09, Vol.12 (1), p.34-34, Article 34 |
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| creator | Naz, Syeda Sohaila Shah, Muhammad Raza Islam, Nazar Ul Khan, Ajmal Nazir, Samina Qaisar, Sara Alam, Syed Sartaj |
| description | Conjugated and drug loaded silver nanoparticles are getting an increased attention for various biomedical applications. Nanoconjugates showed significant enhancement in biological activity in comparison to free drug molecules. In this perspective, we report the synthesis of bioactive silver capped with 5-Amino-?-resorcylic acid hydrochloride dihydrate (AR). The in vitro antimicrobial (antibacterial, antifungal), enzyme inhibition (xanthine oxidase, urease, carbonic anhydrase, ?-chymotrypsin, cholinesterase) and antioxidant activities of the developed nanostructures was investigated before and after conjugation to silver metal. The conjugation of AR to silver was confirmed through FTIR, UV-vis and TEM techniques. The amount of AR conjugated with silver was characterized through UV-vis spectroscopy and found to be 9% by weight. The stability of synthesized nanoconjugates against temperature, high salt concentration and pH was found to be good. Nanoconjugates, showed significant synergic enzyme inhibition effect against xanthine and urease enzymes in comparison to standard drugs, pure ligand and silver. Our synthesized nanoconjugate was found be to efficient selective xanthine and urease inhibitors in comparison to Ag and AR. On a per weight basis, our nanoconjugates required less amount of AR (about 11 times) for inhibition of these enzymes. |
| doi_str_mv | 10.1186/s12951-014-0034-8 |
| format | Article |
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Nanoconjugates showed significant enhancement in biological activity in comparison to free drug molecules. In this perspective, we report the synthesis of bioactive silver capped with 5-Amino-?-resorcylic acid hydrochloride dihydrate (AR). The in vitro antimicrobial (antibacterial, antifungal), enzyme inhibition (xanthine oxidase, urease, carbonic anhydrase, ?-chymotrypsin, cholinesterase) and antioxidant activities of the developed nanostructures was investigated before and after conjugation to silver metal. The conjugation of AR to silver was confirmed through FTIR, UV-vis and TEM techniques. The amount of AR conjugated with silver was characterized through UV-vis spectroscopy and found to be 9% by weight. The stability of synthesized nanoconjugates against temperature, high salt concentration and pH was found to be good. Nanoconjugates, showed significant synergic enzyme inhibition effect against xanthine and urease enzymes in comparison to standard drugs, pure ligand and silver. Our synthesized nanoconjugate was found be to efficient selective xanthine and urease inhibitors in comparison to Ag and AR. On a per weight basis, our nanoconjugates required less amount of AR (about 11 times) for inhibition of these enzymes.</description><identifier>ISSN: 1477-3155</identifier><identifier>EISSN: 1477-3155</identifier><identifier>DOI: 10.1186/s12951-014-0034-8</identifier><identifier>PMID: 25201390</identifier><language>eng</language><publisher>London: BioMed Central Ltd</publisher><subject>Acids ; Aqueous solutions ; Biomedical engineering ; Chymotrypsin ; Colleges & universities ; Conjugation ; Drugs ; Enzymes ; Gold ; Inhibition ; Inhibitors ; Methods ; Nanoparticles ; Nanostructure ; Physics ; Physiological aspects ; Silver ; Spectrum analysis ; Xanthines</subject><ispartof>Journal of nanobiotechnology, 2014-09, Vol.12 (1), p.34-34, Article 34</ispartof><rights>COPYRIGHT 2014 BioMed Central Ltd.</rights><rights>2014 Naz et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.</rights><rights>Copyright © 2014 Naz et al.; licensee BioMed Central Ltd. 2014 Naz et al.; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3838-9c763b7e4cc1140a5b0f48d46e84c3aa6a15f9e135df431d057f3ee67dec4f9f3</citedby><cites>FETCH-LOGICAL-c3838-9c763b7e4cc1140a5b0f48d46e84c3aa6a15f9e135df431d057f3ee67dec4f9f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422292/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422292/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Naz, Syeda Sohaila</creatorcontrib><creatorcontrib>Shah, Muhammad Raza</creatorcontrib><creatorcontrib>Islam, Nazar Ul</creatorcontrib><creatorcontrib>Khan, Ajmal</creatorcontrib><creatorcontrib>Nazir, Samina</creatorcontrib><creatorcontrib>Qaisar, Sara</creatorcontrib><creatorcontrib>Alam, Syed Sartaj</creatorcontrib><title>Synthesis and bioactivities of silver nanoparticles capped with 5-Amino-?-resorcylic acid hydrochloride dihydrate</title><title>Journal of nanobiotechnology</title><description>Conjugated and drug loaded silver nanoparticles are getting an increased attention for various biomedical applications. Nanoconjugates showed significant enhancement in biological activity in comparison to free drug molecules. In this perspective, we report the synthesis of bioactive silver capped with 5-Amino-?-resorcylic acid hydrochloride dihydrate (AR). The in vitro antimicrobial (antibacterial, antifungal), enzyme inhibition (xanthine oxidase, urease, carbonic anhydrase, ?-chymotrypsin, cholinesterase) and antioxidant activities of the developed nanostructures was investigated before and after conjugation to silver metal. The conjugation of AR to silver was confirmed through FTIR, UV-vis and TEM techniques. The amount of AR conjugated with silver was characterized through UV-vis spectroscopy and found to be 9% by weight. The stability of synthesized nanoconjugates against temperature, high salt concentration and pH was found to be good. Nanoconjugates, showed significant synergic enzyme inhibition effect against xanthine and urease enzymes in comparison to standard drugs, pure ligand and silver. Our synthesized nanoconjugate was found be to efficient selective xanthine and urease inhibitors in comparison to Ag and AR. On a per weight basis, our nanoconjugates required less amount of AR (about 11 times) for inhibition of these enzymes.</description><subject>Acids</subject><subject>Aqueous solutions</subject><subject>Biomedical engineering</subject><subject>Chymotrypsin</subject><subject>Colleges & universities</subject><subject>Conjugation</subject><subject>Drugs</subject><subject>Enzymes</subject><subject>Gold</subject><subject>Inhibition</subject><subject>Inhibitors</subject><subject>Methods</subject><subject>Nanoparticles</subject><subject>Nanostructure</subject><subject>Physics</subject><subject>Physiological aspects</subject><subject>Silver</subject><subject>Spectrum analysis</subject><subject>Xanthines</subject><issn>1477-3155</issn><issn>1477-3155</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkl2L1DAUhoso7of-AO8K3uhF15x8tOmNMiyuLiwIrl6HTHIyzdJJukk76_x7W2ZRRwQ5Fzk5ed6XcHiL4hWQCwBZv8tAWwEVAV4RwnglnxSnwJumYiDE0z_6k-Is5ztCKOWUPy9OqKAEWEtOi_vbfRg7zD6XOthy7aM2o9_50WMuoyuz73eYyqBDHHQavennudHDgLZ88GNXimq19SFWH6qEOSaz770ptfG27PY2RdP1MXmLpfXLXY_4onjmdJ_x5eN5Xny_-vjt8nN18-XT9eXqpjJMMlm1pqnZukFuDAAnWqyJ49LyGiU3TOtag3AtAhPWcQaWiMYxxLqxaLhrHTsv3h98h2m9RWswjEn3akh-q9NeRe3V8UvwndrEneKcUtrS2eDNo0GK9xPmUW19Ntj3OmCcsoK6gRooNPL_qKhryUFCO6Ov_0Lv4pTCvImF4ryVEshvaqN7VD64OH_RLKZqJVhbt7IRbKYu_kHNZXHrTQzo_Dw_Erw9EszMiD_GjZ5yVte3X49ZOLAmxZwTul-rA6KW-KlD_NQcP7XET0n2E2qFy3o</recordid><startdate>20140909</startdate><enddate>20140909</enddate><creator>Naz, Syeda Sohaila</creator><creator>Shah, Muhammad Raza</creator><creator>Islam, Nazar Ul</creator><creator>Khan, Ajmal</creator><creator>Nazir, Samina</creator><creator>Qaisar, Sara</creator><creator>Alam, Syed Sartaj</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7QO</scope><scope>7TB</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7U5</scope><scope>L7M</scope><scope>5PM</scope></search><sort><creationdate>20140909</creationdate><title>Synthesis and bioactivities of silver nanoparticles capped with 5-Amino-?-resorcylic acid hydrochloride dihydrate</title><author>Naz, Syeda Sohaila ; Shah, Muhammad Raza ; Islam, Nazar Ul ; Khan, Ajmal ; Nazir, Samina ; Qaisar, Sara ; Alam, Syed Sartaj</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3838-9c763b7e4cc1140a5b0f48d46e84c3aa6a15f9e135df431d057f3ee67dec4f9f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Acids</topic><topic>Aqueous solutions</topic><topic>Biomedical engineering</topic><topic>Chymotrypsin</topic><topic>Colleges & universities</topic><topic>Conjugation</topic><topic>Drugs</topic><topic>Enzymes</topic><topic>Gold</topic><topic>Inhibition</topic><topic>Inhibitors</topic><topic>Methods</topic><topic>Nanoparticles</topic><topic>Nanostructure</topic><topic>Physics</topic><topic>Physiological aspects</topic><topic>Silver</topic><topic>Spectrum analysis</topic><topic>Xanthines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Naz, Syeda Sohaila</creatorcontrib><creatorcontrib>Shah, Muhammad Raza</creatorcontrib><creatorcontrib>Islam, Nazar Ul</creatorcontrib><creatorcontrib>Khan, Ajmal</creatorcontrib><creatorcontrib>Nazir, Samina</creatorcontrib><creatorcontrib>Qaisar, Sara</creatorcontrib><creatorcontrib>Alam, Syed Sartaj</creatorcontrib><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Materials Science Collection</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of nanobiotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Naz, Syeda Sohaila</au><au>Shah, Muhammad Raza</au><au>Islam, Nazar Ul</au><au>Khan, Ajmal</au><au>Nazir, Samina</au><au>Qaisar, Sara</au><au>Alam, Syed Sartaj</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and bioactivities of silver nanoparticles capped with 5-Amino-?-resorcylic acid hydrochloride dihydrate</atitle><jtitle>Journal of nanobiotechnology</jtitle><date>2014-09-09</date><risdate>2014</risdate><volume>12</volume><issue>1</issue><spage>34</spage><epage>34</epage><pages>34-34</pages><artnum>34</artnum><issn>1477-3155</issn><eissn>1477-3155</eissn><abstract>Conjugated and drug loaded silver nanoparticles are getting an increased attention for various biomedical applications. Nanoconjugates showed significant enhancement in biological activity in comparison to free drug molecules. In this perspective, we report the synthesis of bioactive silver capped with 5-Amino-?-resorcylic acid hydrochloride dihydrate (AR). The in vitro antimicrobial (antibacterial, antifungal), enzyme inhibition (xanthine oxidase, urease, carbonic anhydrase, ?-chymotrypsin, cholinesterase) and antioxidant activities of the developed nanostructures was investigated before and after conjugation to silver metal. The conjugation of AR to silver was confirmed through FTIR, UV-vis and TEM techniques. The amount of AR conjugated with silver was characterized through UV-vis spectroscopy and found to be 9% by weight. The stability of synthesized nanoconjugates against temperature, high salt concentration and pH was found to be good. Nanoconjugates, showed significant synergic enzyme inhibition effect against xanthine and urease enzymes in comparison to standard drugs, pure ligand and silver. Our synthesized nanoconjugate was found be to efficient selective xanthine and urease inhibitors in comparison to Ag and AR. On a per weight basis, our nanoconjugates required less amount of AR (about 11 times) for inhibition of these enzymes.</abstract><cop>London</cop><pub>BioMed Central Ltd</pub><pmid>25201390</pmid><doi>10.1186/s12951-014-0034-8</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acids Aqueous solutions Biomedical engineering Chymotrypsin Colleges & universities Conjugation Drugs Enzymes Gold Inhibition Inhibitors Methods Nanoparticles Nanostructure Physics Physiological aspects Silver Spectrum analysis Xanthines |
| title | Synthesis and bioactivities of silver nanoparticles capped with 5-Amino-?-resorcylic acid hydrochloride dihydrate |
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