Identifying candidate causal variants responsible for altered activity of the ABCB1 multidrug resistance gene

The difficulty of fine localizing the polymorphisms responsible for genotype-phenotype correlations is emerging as an important constraint in the implementation and interpretation of genetic association studies, and calls for the definition of protocols for the follow-up of associated variants. One...

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Veröffentlicht in:	Genome research 2004-07, Vol.14 (7), p.1333-1344
Hauptverfasser:	Soranzo, Nicole, Cavalleri, Gianpiero L, Weale, Michael E, Wood, Nicholas W, Depondt, Chantal, Marguerie, Richard, Sisodiya, Sanjay M, Goldstein, David B
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Anticonvulsants - metabolism Anticonvulsants - therapeutic use ATP-Binding Cassette, Sub-Family B, Member 1 - genetics ATP-Binding Cassette, Sub-Family B, Member 1 - physiology Chromosome Mapping - methods Chromosome Mapping - statistics & numerical data Cohort Studies Conserved Sequence - genetics Conserved Sequence - physiology Drug Resistance, Multiple - genetics Drug Resistance, Multiple - physiology Epilepsy - drug therapy Epilepsy - metabolism Evolution, Molecular Genetic Markers - genetics Genetic Testing - methods Genetic Testing - statistics & numerical data Genetic Variation - genetics Genotype Haplotypes - genetics Humans Introns - genetics Letters Linkage Disequilibrium - genetics Pan troglodytes - genetics Phenotype Polymorphism, Single Nucleotide - genetics Polymorphism, Single Nucleotide - physiology Polymorphism, Single Nucleotide - radiation effects
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