Abrupt and durable remission of Henoch–Schönlein purpura nephritis with cyclosporine A

Abrupt and durable remission of Henoch–Schönlein purpura nephritis with cyclosporine A

Henoch–Schönlein purpura glomerulonephritis (HSP-GN) is a common form of systemic small vessel vasculitis in children. Although prognosis is usually favourable, the disease is occasionally associated with a risk of renal insufficiency. Various immunosuppressive agents have been used in patients with...

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Veröffentlicht in:Clinical kidney journal 2008-10, Vol.1 (5), p.300-302
Hauptverfasser: Georgaki-Angelaki, Eleni, Kostaridou, Stavroula, Lourida, Athanasia, Petraki, C., Lagona, Evagelia
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Case Report
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container_end_page 302
container_issue 5
container_start_page 300
container_title Clinical kidney journal
container_volume 1
creator Georgaki-Angelaki, Eleni
Kostaridou, Stavroula
Lourida, Athanasia
Petraki, C.
Lagona, Evagelia
description Henoch–Schönlein purpura glomerulonephritis (HSP-GN) is a common form of systemic small vessel vasculitis in children. Although prognosis is usually favourable, the disease is occasionally associated with a risk of renal insufficiency. Various immunosuppressive agents have been used in patients with severe HSP-GN, but none have shown convincing favourable effects. We report a case of biopsy-proven HSP-related GN in a 4-year-old girl that responded remarkably well to cyclosporine A (CsA), following failure to respond to other immunosuppressive agents. At 8 months post-CsA treatment, repeat renal biopsy findings were consistent with histological improvement. We conclude that CsA treatment not only exerts beneficial effects on resistant HSP-related GN but may also arrest progression of the disease.
doi_str_mv 10.1093/ndtplus/sfn105
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title Abrupt and durable remission of Henoch–Schönlein purpura nephritis with cyclosporine A
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