pH-sensitive oncolytic adenovirus hybrid targeting acidic tumor microenvironment and angiogenesis

Although oncolytic adenoviruses (Ads) are an attractive option for cancer gene therapy, the intravenous administration of naked Ad still encounters unfavorable host responses, non-specific interactions, and heterogeneity in targeted cancer cells. To overcome these obstacles and achieve specific targ...

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Veröffentlicht in:	Journal of controlled release 2015-05, Vol.205, p.134-143
Hauptverfasser:	Choi, Joung-Woo, Jung, Soo-Jung, Kasala, Dayananda, Hwang, June Kyu, Hu, Jun, Bae, You Han, Yun, Chae-Ok
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenoviridae - immunology Adenoviridae - pathogenicity Adenovirus E1A Proteins - genetics Adenovirus E1B Proteins - genetics Animals Cancer gene therapy Cell Hypoxia Cell Movement Gene Deletion Gene Expression Regulation, Neoplastic Gene Expression Regulation, Viral HEK293 Cells Histidine - chemistry Humans Hydrogen-Ion Concentration Hypoxia Immunity, Innate MCF-7 Cells Mice, Nude Mutation Neoplasm Invasiveness Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Neoplasms - therapy Neoplasms - virology Neovascularization, Physiologic Oncolytic adenovirus Oncolytic Virotherapy - adverse effects Oncolytic Virotherapy - methods Oncolytic Viruses - genetics Oncolytic Viruses - immunology Oncolytic Viruses - pathogenicity Peptides - chemistry pH-sensitive polymers Polyethylene Glycols - chemistry Rats, Sprague-Dawley Systemic administration Time Factors Tissue Culture Techniques Transduction, Genetic Tumor Burden Tumor Microenvironment Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism Xenograft Model Antitumor Assays
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