The effect of salt on renal damage in eNOS-deficient mice
African Americans have an increased incidence of end-stage renal disease and are characterized as having reduced bioavailability of nitric oxide and salt-sensitivity. We propose that endothelial nitric oxide synthase (eNOS) knockout mice (eNOS −/− ) are a suitable model of hypertension-associated re...
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| Veröffentlicht in: | Hypertension research 2010-02, Vol.33 (2), p.170-176 |
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| creator | Daumerie, Geraldine Bridges, LaKeesha Yancey, Sadiqa Davis, Wendell Huang, Paul Loscalzo, Joseph Pointer, Mildred A |
| description | African Americans have an increased incidence of end-stage renal disease and are characterized as having reduced bioavailability of nitric oxide and salt-sensitivity. We propose that endothelial nitric oxide synthase (eNOS) knockout mice (eNOS
−/−
) are a suitable model of hypertension-associated renal injury as seen in African Americans. Therefore, the purpose of this study was to determine whether older eNOS
−/−
mice have hypertension-associated renal injury and if dietary salt modulates this injury. Six-month-old eNOS
−/−
mice were placed on 0.12%, 0.45% or 8% NaCl diet for 8 weeks and blood pressure measured weekly; kidneys were collected for pathology evaluation and scoring at the end of the 8-week period. Mice deficient of eNOS were hypertensive at baseline compared with control mice in all three groups (128±3
vs
. 112±3,
P |
| doi_str_mv | 10.1038/hr.2009.197 |
| format | Article |
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−/−
) are a suitable model of hypertension-associated renal injury as seen in African Americans. Therefore, the purpose of this study was to determine whether older eNOS
−/−
mice have hypertension-associated renal injury and if dietary salt modulates this injury. Six-month-old eNOS
−/−
mice were placed on 0.12%, 0.45% or 8% NaCl diet for 8 weeks and blood pressure measured weekly; kidneys were collected for pathology evaluation and scoring at the end of the 8-week period. Mice deficient of eNOS were hypertensive at baseline compared with control mice in all three groups (128±3
vs
. 112±3,
P
<0.05). Blood pressure was significantly elevated from baseline in eNOS
−/−
on 0.45 and 8% salt diets (
P
<0.02). The composite renal pathology scores for eNOS
−/−
mice were significantly greater than wild-type mice, indicating high salt intake exacerbates the injury (
P
<0.001
vs
. normal salt diet). eNOS
−/−
mice may be used as a model of salt-induced and hypertension-associated renal injury as seen in African Americans.</description><identifier>ISSN: 0916-9636</identifier><identifier>EISSN: 1348-4214</identifier><identifier>DOI: 10.1038/hr.2009.197</identifier><identifier>PMID: 19960018</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>African Americans ; Animals ; Blood Pressure ; Cardiomegaly - etiology ; Geriatrics/Gerontology ; Health Promotion and Disease Prevention ; Humans ; Hypertension - pathology ; Internal Medicine ; Kidney - pathology ; Medicine ; Medicine & Public Health ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Nitric Oxide Synthase Type III - deficiency ; Nitric Oxide Synthase Type III - physiology ; Obstetrics/Perinatology/Midwifery ; Organ Size ; original-article ; Public Health ; Sodium Chloride, Dietary - administration & dosage</subject><ispartof>Hypertension research, 2010-02, Vol.33 (2), p.170-176</ispartof><rights>The Japanese Society of Hypertension 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-f9fdcb9daa52727688c59a2bc036c0086f6a1ef8ed428b8413973c8d5a85d4f63</citedby><cites>FETCH-LOGICAL-c470t-f9fdcb9daa52727688c59a2bc036c0086f6a1ef8ed428b8413973c8d5a85d4f63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19960018$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Daumerie, Geraldine</creatorcontrib><creatorcontrib>Bridges, LaKeesha</creatorcontrib><creatorcontrib>Yancey, Sadiqa</creatorcontrib><creatorcontrib>Davis, Wendell</creatorcontrib><creatorcontrib>Huang, Paul</creatorcontrib><creatorcontrib>Loscalzo, Joseph</creatorcontrib><creatorcontrib>Pointer, Mildred A</creatorcontrib><title>The effect of salt on renal damage in eNOS-deficient mice</title><title>Hypertension research</title><addtitle>Hypertens Res</addtitle><addtitle>Hypertens Res</addtitle><description>African Americans have an increased incidence of end-stage renal disease and are characterized as having reduced bioavailability of nitric oxide and salt-sensitivity. We propose that endothelial nitric oxide synthase (eNOS) knockout mice (eNOS
−/−
) are a suitable model of hypertension-associated renal injury as seen in African Americans. Therefore, the purpose of this study was to determine whether older eNOS
−/−
mice have hypertension-associated renal injury and if dietary salt modulates this injury. Six-month-old eNOS
−/−
mice were placed on 0.12%, 0.45% or 8% NaCl diet for 8 weeks and blood pressure measured weekly; kidneys were collected for pathology evaluation and scoring at the end of the 8-week period. Mice deficient of eNOS were hypertensive at baseline compared with control mice in all three groups (128±3
vs
. 112±3,
P
<0.05). Blood pressure was significantly elevated from baseline in eNOS
−/−
on 0.45 and 8% salt diets (
P
<0.02). The composite renal pathology scores for eNOS
−/−
mice were significantly greater than wild-type mice, indicating high salt intake exacerbates the injury (
P
<0.001
vs
. normal salt diet). eNOS
−/−
mice may be used as a model of salt-induced and hypertension-associated renal injury as seen in African Americans.</description><subject>African Americans</subject><subject>Animals</subject><subject>Blood Pressure</subject><subject>Cardiomegaly - etiology</subject><subject>Geriatrics/Gerontology</subject><subject>Health Promotion and Disease Prevention</subject><subject>Humans</subject><subject>Hypertension - pathology</subject><subject>Internal Medicine</subject><subject>Kidney - pathology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Nitric Oxide Synthase Type III - deficiency</subject><subject>Nitric Oxide Synthase Type III - physiology</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>Organ Size</subject><subject>original-article</subject><subject>Public Health</subject><subject>Sodium Chloride, Dietary - administration & dosage</subject><issn>0916-9636</issn><issn>1348-4214</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkDtPwzAQgC0EoqUwsaNsDJBix45jL0io4iVVdKDMluOcm1R5FDtB4t_jqhUPiemG-_Td6UPonOApwVTclG6aYCynRGYHaEwoEzFLCDtEYywJjyWnfIROvF9jnIhUkmM0IlJyjIkYI7ksIQJrwfRRZyOv6zDbyEGr66jQjV5BVLURvCxe4wJsZSpo-6ipDJyiI6trD2f7OUFvD_fL2VM8Xzw-z-7msWEZ7mMrbWFyWWidJlmScSFMKnWSG0y5wVhwyzUBK6BgicgFI1Rm1Igi1SItmOV0gm533s2QN1CYcN_pWm1c1Wj3qTpdqb-btirVqvtQjIUimAbB5V7guvcBfK-ayhuoa91CN3iVUSpDjEQG8mpHGtd578B-XyFYbVur0qltaxXMgb74_dgPu48bgOsd4MOqXYFT625wIaz_1_cF9i2IFg</recordid><startdate>20100201</startdate><enddate>20100201</enddate><creator>Daumerie, Geraldine</creator><creator>Bridges, LaKeesha</creator><creator>Yancey, Sadiqa</creator><creator>Davis, Wendell</creator><creator>Huang, Paul</creator><creator>Loscalzo, Joseph</creator><creator>Pointer, Mildred A</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20100201</creationdate><title>The effect of salt on renal damage in eNOS-deficient mice</title><author>Daumerie, Geraldine ; Bridges, LaKeesha ; Yancey, Sadiqa ; Davis, Wendell ; Huang, Paul ; Loscalzo, Joseph ; Pointer, Mildred A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-f9fdcb9daa52727688c59a2bc036c0086f6a1ef8ed428b8413973c8d5a85d4f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>African Americans</topic><topic>Animals</topic><topic>Blood Pressure</topic><topic>Cardiomegaly - etiology</topic><topic>Geriatrics/Gerontology</topic><topic>Health Promotion and Disease Prevention</topic><topic>Humans</topic><topic>Hypertension - pathology</topic><topic>Internal Medicine</topic><topic>Kidney - pathology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>Nitric Oxide Synthase Type III - deficiency</topic><topic>Nitric Oxide Synthase Type III - physiology</topic><topic>Obstetrics/Perinatology/Midwifery</topic><topic>Organ Size</topic><topic>original-article</topic><topic>Public Health</topic><topic>Sodium Chloride, Dietary - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Daumerie, Geraldine</creatorcontrib><creatorcontrib>Bridges, LaKeesha</creatorcontrib><creatorcontrib>Yancey, Sadiqa</creatorcontrib><creatorcontrib>Davis, Wendell</creatorcontrib><creatorcontrib>Huang, Paul</creatorcontrib><creatorcontrib>Loscalzo, Joseph</creatorcontrib><creatorcontrib>Pointer, Mildred A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Hypertension research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Daumerie, Geraldine</au><au>Bridges, LaKeesha</au><au>Yancey, Sadiqa</au><au>Davis, Wendell</au><au>Huang, Paul</au><au>Loscalzo, Joseph</au><au>Pointer, Mildred A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of salt on renal damage in eNOS-deficient mice</atitle><jtitle>Hypertension research</jtitle><stitle>Hypertens Res</stitle><addtitle>Hypertens Res</addtitle><date>2010-02-01</date><risdate>2010</risdate><volume>33</volume><issue>2</issue><spage>170</spage><epage>176</epage><pages>170-176</pages><issn>0916-9636</issn><eissn>1348-4214</eissn><abstract>African Americans have an increased incidence of end-stage renal disease and are characterized as having reduced bioavailability of nitric oxide and salt-sensitivity. We propose that endothelial nitric oxide synthase (eNOS) knockout mice (eNOS
−/−
) are a suitable model of hypertension-associated renal injury as seen in African Americans. Therefore, the purpose of this study was to determine whether older eNOS
−/−
mice have hypertension-associated renal injury and if dietary salt modulates this injury. Six-month-old eNOS
−/−
mice were placed on 0.12%, 0.45% or 8% NaCl diet for 8 weeks and blood pressure measured weekly; kidneys were collected for pathology evaluation and scoring at the end of the 8-week period. Mice deficient of eNOS were hypertensive at baseline compared with control mice in all three groups (128±3
vs
. 112±3,
P
<0.05). Blood pressure was significantly elevated from baseline in eNOS
−/−
on 0.45 and 8% salt diets (
P
<0.02). The composite renal pathology scores for eNOS
−/−
mice were significantly greater than wild-type mice, indicating high salt intake exacerbates the injury (
P
<0.001
vs
. normal salt diet). eNOS
−/−
mice may be used as a model of salt-induced and hypertension-associated renal injury as seen in African Americans.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>19960018</pmid><doi>10.1038/hr.2009.197</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Hypertension research, 2010-02, Vol.33 (2), p.170-176 |
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| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | African Americans Animals Blood Pressure Cardiomegaly - etiology Geriatrics/Gerontology Health Promotion and Disease Prevention Humans Hypertension - pathology Internal Medicine Kidney - pathology Medicine Medicine & Public Health Mice Mice, Inbred C57BL Mice, Knockout Nitric Oxide Synthase Type III - deficiency Nitric Oxide Synthase Type III - physiology Obstetrics/Perinatology/Midwifery Organ Size original-article Public Health Sodium Chloride, Dietary - administration & dosage |
| title | The effect of salt on renal damage in eNOS-deficient mice |
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