Modulation of NFAT-dependent gene expression by the RhoA signaling pathway in T cells

We have reported previously that p115Rho guanine nucleotide exchange factor, its upstream activator Gα13, and its effector RhoA are able to inhibit HIV‐1 replication. Here, we show that RhoA is able to inhibit HIV‐1 gene expression through the NFAT‐binding site in the HIV long‐terminal repeat. Const...

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