Novel APC promoter and exon 1B deletion and allelic silencing in three mutation-negative classic familial adenomatous polyposis families

The overwhelming majority (approximately 80%) of individuals with classic familial adenomatous polyposis (FAP) exhibit mutations in the coding sequence of the adenomatous polyposis coli (APC) tumor suppressor gene. Families without detectable APC mutations are unable to benefit from the use of genet...

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Veröffentlicht in:	Genome medicine 2015-05, Vol.7 (1), p.42-42, Article 42
Hauptverfasser:	Lin, Yiing, Lin, Shin, Baxter, Melanie D, Lin, Lawrence, Kennedy, Susan M, Zhang, Zhengyan, Goodfellow, Paul J, Chapman, William C, Davidson, Nicholas O
Format:	Artikel
Sprache:	eng
Schlagworte:	Genes Genetic aspects Genetic screening Polyposis, Familial RNA Single nucleotide polymorphisms
Online-Zugang:	Volltext
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