Oncolytic adenovirus expressing interferon alpha in a syngeneic Syrian hamster model for the treatment of pancreatic cancer

Background The addition of interferon (IFN) alpha to adjuvant chemoradiotherapy regimens resulted in remarkable improvements in survival for pancreatic cancer patients. However, systemic toxicities and insufficient levels of IFN at the tumor sites have limited its widespread adoption in treatment sc...

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Veröffentlicht in:	Surgery 2015-05, Vol.157 (5), p.888-898
Hauptverfasser:	LaRocca, Christopher J., MD, Han, Joohee, BS, Gavrikova, Tatyana, MS, Armstrong, Leonard, MD, MS, Oliveira, Amanda R., DVM, MS, Shanley, Ryan, MS, Vickers, Selwyn M., MD, Yamamoto, Masato, MD, PhD, Davydova, Julia, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - metabolism Animals Carcinoma - therapy Cell Line, Tumor Cricetinae Female Humans Immunologic Factors - administration & dosage Immunologic Factors - metabolism Interferon-alpha - administration & dosage Interferon-alpha - metabolism Mesocricetus Neoplasms, Experimental Oncolytic Virotherapy - methods Pancreatic Neoplasms - therapy Surgery
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