PET of c-Met in Cancer with ⁶⁴Cu-Labeled Hepatocyte Growth Factor

The hepatocyte growth factor (HGF) and its receptor, c-Met, are actively involved in tumor progression and metastasis and are closely associated with a poor prognostic outcome for cancer patients. Thus, the development of PET agents that can assess c-Met expression would be extremely useful for diag...

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Veröffentlicht in:	The Journal of nuclear medicine (1978) 2015-05, Vol.56 (5), p.758-763
Hauptverfasser:	Luo, Haiming, Hong, Hao, Slater, Michael R, Graves, Stephen A, Shi, Sixiang, Yang, Yunan, Nickles, Robert J, Fan, Frank, Cai, Weibo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Transport Breast Neoplasms - diagnostic imaging Breast Neoplasms - pathology Cell Line, Tumor Copper Radioisotopes Gene Expression Regulation, Neoplastic Glioblastoma - diagnostic imaging Glioblastoma - pathology HEK293 Cells Hepatocyte Growth Factor - chemistry Hepatocyte Growth Factor - metabolism Hepatocyte Growth Factor - pharmacokinetics Heterocyclic Compounds - chemistry Humans Mice Positron-Emission Tomography - methods Proto-Oncogene Proteins c-met - metabolism Tissue Distribution
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