Increasing Adipocyte Lipoprotein Lipase Improves Glucose Metabolism in High Fat Diet-induced Obesity

Lipid accumulation in liver and skeletal muscle contributes to co-morbidities associated with diabetes and obesity. We made a transgenic mouse in which the adiponectin (Adipoq) promoter drives expression of lipoprotein lipase (LPL) in adipocytes to potentially increase adipose tissue lipid storage....

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Veröffentlicht in:	The Journal of biological chemistry 2015-05, Vol.290 (18), p.11547-11556
Hauptverfasser:	Walton, R. Grace, Zhu, Beibei, Unal, Resat, Spencer, Michael, Sunkara, Manjula, Morris, Andrew J., Charnigo, Richard, Katz, Wendy S., Daugherty, Alan, Howatt, Deborah A., Kern, Philip A., Finlin, Brian S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes - drug effects Adipocytes - metabolism Animals Diet, High-Fat - adverse effects Female Glucose - metabolism Humans Insulin Resistance Lipase Lipoprotein Lipoprotein Lipase - genetics Lipoprotein Lipase - metabolism Male Metabolism Mice Mice, Transgenic Obesity Obesity - enzymology Obesity - genetics Obesity - metabolism Obesity - pathology Phenotype Thiazolidinediones - pharmacology
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