CSTminer: a web tool for the identification of coding and noncoding conserved sequence tags through cross-species genome comparison
The identification and characterization of genome tracts that are highly conserved across species during evolution may contribute significantly to the functional annotation of whole-genome sequences. Indeed, such sequences are likely to correspond to known or unknown coding exons or regulatory motif...
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| Veröffentlicht in: | Nucleic acids research 2004-07, Vol.32 (suppl-2), p.W624-W627 |
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| container_issue | suppl-2 |
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| container_title | Nucleic acids research |
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| creator | Castrignanò, Tiziana Canali, Alessandro Grillo, Giorgio Liuni, Sabino Mignone, Flavio Pesole, Graziano |
| description | The identification and characterization of genome tracts that are highly conserved across species during evolution may contribute significantly to the functional annotation of whole-genome sequences. Indeed, such sequences are likely to correspond to known or unknown coding exons or regulatory motifs. Here, we present a web server implementing a previously developed algorithm that, by comparing user-submitted genome sequences, is able to identify statistically significant conserved blocks and assess their coding or noncoding nature through the measure of a coding potential score. The web tool, available at http://www.caspur.it/CSTminer/, is dynamically interconnected with the Ensembl genome resources and produces a graphical output showing a map of detected conserved sequences and annotated gene features. |
| doi_str_mv | 10.1093/nar/gkh486 |
| format | Article |
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Acids Res</addtitle><date>2004-07-01</date><risdate>2004</risdate><volume>32</volume><issue>suppl-2</issue><spage>W624</spage><epage>W627</epage><pages>W624-W627</pages><issn>0305-1048</issn><eissn>1362-4962</eissn><coden>NARHAD</coden><abstract>The identification and characterization of genome tracts that are highly conserved across species during evolution may contribute significantly to the functional annotation of whole-genome sequences. Indeed, such sequences are likely to correspond to known or unknown coding exons or regulatory motifs. Here, we present a web server implementing a previously developed algorithm that, by comparing user-submitted genome sequences, is able to identify statistically significant conserved blocks and assess their coding or noncoding nature through the measure of a coding potential score. 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| source | MEDLINE; Oxford Journals Open Access Collection; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Animals Computer Graphics Conserved Sequence DNA, Intergenic - analysis Exons Genomics Humans Internet Mice Regulatory Sequences, Nucleic Acid Sequence Tagged Sites Software User-Computer Interface |
| title | CSTminer: a web tool for the identification of coding and noncoding conserved sequence tags through cross-species genome comparison |
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