A nanotherapy strategy significantly enhances anticryptosporidial activity of an inhibitor of bifunctional thymidylate synthase-dihydrofolate reductase from Cryptosporidium

[Display omitted] Cryptosporidiosis, a gastrointestinal disease caused by protozoans of the genus Cryptosporidium, is a common cause of diarrheal diseases and often fatal in immunocompromised individuals. Bifunctional thymidylate synthase-dihydrofolate reductase (TS-DHFR) from Cryptosporidium homini...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2015-05, Vol.25 (10), p.2065-2067
Hauptverfasser:	Mukerjee, Anindita, Iyidogan, Pinar, Castellanos-Gonzalez, Alejandro, Cisneros, José A., Czyzyk, Daniel, Ranjan, Amalendu Prakash, Jorgensen, William L., White, A. Clinton, Vishwanatha, Jamboor K., Anderson, Karen S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiprotozoal Agents - chemical synthesis Antiprotozoal Agents - chemistry Antiprotozoal Agents - pharmacology Binding Sites Cells, Cultured Cryptosporidium - drug effects Cryptosporidium - enzymology Cryptosporidium hominis Dihydrofolate reductase Drug delivery Drug Synergism Models, Molecular Multienzyme Complexes - antagonists & inhibitors Nanoparticle Nanoparticles - chemistry Tetrahydrofolate Dehydrogenase Thymidylate synthase Thymidylate Synthase - antagonists & inhibitors
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