Transient delivery of modified mRNA encoding TERT rapidly extends telomeres in human cells

ABSTRACT Telomere extension has been proposed as a means to improve cell culture and tissue engineering and to treat disease. However, telomere extension by nonviral, nonintegrating methods remains inefficient. Here we report that delivery of modified mRNA encoding TERT to human fibroblasts and myob...

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Veröffentlicht in:	The FASEB journal 2015-05, Vol.29 (5), p.1930-1939
Hauptverfasser:	Ramunas, John, Yakubov, Eduard, Brady, Jennifer J., Corbel, Stéphane Y., Holbrook, Colin, Brandt, Moritz, Stein, Jonathan, Santiago, Juan G., Cooke, John P., Blau, Helen M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Blotting, Western Cell Division Cell Proliferation Cells, Cultured Cellular Senescence - physiology Fetus - cytology Fetus - metabolism Fibroblasts - cytology Fibroblasts - metabolism Flow Cytometry Humans Immunoenzyme Techniques In Situ Hybridization, Fluorescence Lung - cytology Lung - metabolism Myoblasts - cytology Myoblasts - metabolism nucleoside modified mRNA proliferative capacity Real-Time Polymerase Chain Reaction Research Communication Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics senescence telomerase Telomerase - genetics Telomerase - metabolism Telomere - genetics
Online-Zugang:	Volltext
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