Peripheral indoleamine 2,3-dioxygenase1 is required for comorbid depression-like behavior but does not contribute to neuropathic pain in mice

Chronic pain frequently co-occurs with major depressive disorder but the mechanisms are poorly understood. We investigated the contribution of indoleamine-2,3-dioxygenase-1 (IDO1), a rate-limiting enzyme in the conversion of tryptophan to neurotoxic metabolites to this comorbidity using the spared n...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2015-01, Vol.46, p.147-153
Hauptverfasser:	Zhou, Wenjun, Dantzer, Robert, Budac, David P., Walker, Adam K., Mao-Ying, Qi-Liang, Lee, Anna W., Heijnen, Cobi J., Kavelaars, Annemieke
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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