Human and murine pituitary expression of leukemia inhibitory factor. Novel intrapituitary regulation of adrenocorticotropin hormone synthesis and secretion

Leukemia inhibitory factor (LIF) gene expression was detected in human fetal pituitary tissue by expression of LIF mRNA transcripts, protein immunocytochemistry, and immunoelectron microscopy. Fetal LIF immunoreactivity colocalized with 30% of ACTH-expressing cells, approximately 20% of somatotrophs...

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Veröffentlicht in:	The Journal of clinical investigation 1995-03, Vol.95 (3), p.1288-1298
Hauptverfasser:	Akita, S, Webster, J, Ren, S G, Takino, H, Said, J, Zand, O, Melmed, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma - metabolism Adrenocorticotropic Hormone - secretion Animals Cells, Cultured Corticotropin-Releasing Hormone - pharmacology Dose-Response Relationship, Drug Flow Cytometry Growth Inhibitors - biosynthesis Growth Inhibitors - genetics Growth Inhibitors - immunology Growth Inhibitors - pharmacology Humans Immunohistochemistry Interleukin-6 Leukemia Inhibitory Factor Lymphokines - biosynthesis Lymphokines - genetics Lymphokines - immunology Mice Microscopy, Immunoelectron Neutralization Tests Oncostatin M Peptides - pharmacology Pituitary Gland - drug effects Pituitary Gland - embryology Pituitary Gland - metabolism Pituitary Gland - ultrastructure Pituitary Neoplasms - metabolism Pro-Opiomelanocortin - biosynthesis Pro-Opiomelanocortin - genetics RNA, Messenger - analysis
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