Inhibition of ERK1/2 down-regulates the Hippo/YAP signaling pathway in human NSCLC cells

Alterations of the EGFR/ERK and Hippo/YAP pathway have been found in non-small cell lung cancer (NSCLC). Herein, we show that ERK1 and ERK2 have an effect on the Hippo/YAP pathway in human NSCLC cells. Firstly, inhibition of ERK1/2 by siRNA or small-molecular inhibitors decreased the YAP protein lev...

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Veröffentlicht in:	Oncotarget 2015-02, Vol.6 (6), p.4357-4368
Hauptverfasser:	You, Bin, Yang, Yi-Lin, Xu, Zhidong, Dai, Yuyuan, Liu, Shu, Mao, Jian-Hua, Tetsu, Osamu, Li, Hui, Jablons, David M, You, Liang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Cell Biology Cell Line, Tumor Cell Movement - physiology Down-Regulation Gene Expression Regulation, Neoplastic Humans Immunohistochemistry Lung Neoplasms - metabolism Lung Neoplasms - pathology Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Neoplasm Invasiveness - pathology Oncology Phosphoproteins - metabolism Protein-Serine-Threonine Kinases - metabolism Real-Time Polymerase Chain Reaction Research Paper RNA, Small Interfering Signal Transduction - physiology Transcription Factors Transfection
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