SKI2162, an inhibitor of the TGF-β type I receptor (ALK5), inhibits radiation-induced fibrosis in mice

Here we demonstrated that SKI2162, a small-molecule inhibitor of the TGF-β type I receptor (ALK5), prevented radiation-induced fibrosis (RIF) in mice. SKI2162 inhibited phosphorylation of Smad and induction of RIF-related genes in vitro. In RIF a mouse model, SKI2162 reduced late skin reactions and...

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Veröffentlicht in:	Oncotarget 2015-02, Vol.6 (6), p.4171-4179
Hauptverfasser:	Park, Jin-hong, Ryu, Seung-Hee, Choi, Eun Kyung, Ahn, Seung Do, Park, Euisun, Choi, Kyung-Chul, Lee, Sang-wook
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Disease Models, Animal Fibrosis - etiology Fibrosis - prevention & control Humans Keratinocytes - drug effects Keratinocytes - metabolism Male Mice Mice, Inbred BALB C Neoplasms - radiotherapy Phosphorylation Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - metabolism Radiation Injuries, Experimental - enzymology Radiation Injuries, Experimental - prevention & control Radiation-Protective Agents - pharmacology Random Allocation Receptors, Transforming Growth Factor beta - antagonists & inhibitors Receptors, Transforming Growth Factor beta - metabolism Research Paper Signal Transduction - drug effects Smad2 Protein - metabolism Smad3 Protein - metabolism
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