Histone deacetylase inhibitors and cell death
Histone deacetylases (HDACs) are a vast family of enzymes involved in chromatin remodeling and have crucial roles in numerous biological processes, largely through their repressive influence on transcription. In addition to modifying histones, HDACs also target many other non-histone protein substra...
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| Veröffentlicht in: | Cellular and molecular life sciences : CMLS 2014-10, Vol.71 (20), p.3885-3901 |
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| creator | Zhang, Jing Zhong, Qing |
| description | Histone deacetylases (HDACs) are a vast family of enzymes involved in chromatin remodeling and have crucial roles in numerous biological processes, largely through their repressive influence on transcription. In addition to modifying histones, HDACs also target many other non-histone protein substrates to regulate gene expression. Recently, HDACs have gained growing attention as HDAC-inhibiting compounds are being developed as promising cancer therapeutics. Histone deacetylase inhibitors (HDACi) have been shown to induce differentiation, cell cycle arrest, apoptosis, autophagy and necrosis in a variety of transformed cell lines. In this review, we mainly discuss how HDACi may elicit a therapeutic response to human cancers through different cell death pathways, in particular, apoptosis and autophagy. |
| doi_str_mv | 10.1007/s00018-014-1656-6 |
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In addition to modifying histones, HDACs also target many other non-histone protein substrates to regulate gene expression. Recently, HDACs have gained growing attention as HDAC-inhibiting compounds are being developed as promising cancer therapeutics. Histone deacetylase inhibitors (HDACi) have been shown to induce differentiation, cell cycle arrest, apoptosis, autophagy and necrosis in a variety of transformed cell lines. In this review, we mainly discuss how HDACi may elicit a therapeutic response to human cancers through different cell death pathways, in particular, apoptosis and autophagy.</description><identifier>ISSN: 1420-682X</identifier><identifier>EISSN: 1420-9071</identifier><identifier>DOI: 10.1007/s00018-014-1656-6</identifier><identifier>PMID: 24898083</identifier><language>eng</language><publisher>Basel: Springer-Verlag</publisher><subject>apoptosis ; autophagy ; Benzamides - chemistry ; Benzamides - pharmacology ; Benzamides - therapeutic use ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; cell cycle checkpoints ; Cell death ; Cell Death - drug effects ; Cells ; chromatin ; Fatty Acids, Volatile - chemistry ; Fatty Acids, Volatile - pharmacology ; Fatty Acids, Volatile - therapeutic use ; gene expression ; histone deacetylase ; Histone Deacetylase Inhibitors - chemistry ; Histone Deacetylase Inhibitors - pharmacology ; Histone Deacetylase Inhibitors - therapeutic use ; Histone Deacetylases - chemistry ; Histone Deacetylases - metabolism ; histones ; Humans ; Hydroxamic Acids - chemistry ; Hydroxamic Acids - pharmacology ; Hydroxamic Acids - therapeutic use ; Inhibitor drugs ; Life Sciences ; necrosis ; neoplasms ; Neoplasms - drug therapy ; Peptides, Cyclic - chemistry ; Peptides, Cyclic - pharmacology ; Peptides, Cyclic - therapeutic use ; Review ; Signal Transduction - drug effects ; therapeutics</subject><ispartof>Cellular and molecular life sciences : CMLS, 2014-10, Vol.71 (20), p.3885-3901</ispartof><rights>Springer Basel 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c630t-718b50dabb26849e75122ce035ac84ae8904379010ea4a7f7f586476b53c73813</citedby><cites>FETCH-LOGICAL-c630t-718b50dabb26849e75122ce035ac84ae8904379010ea4a7f7f586476b53c73813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414051/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414051/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,41488,42557,51319,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24898083$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Jing</creatorcontrib><creatorcontrib>Zhong, Qing</creatorcontrib><title>Histone deacetylase inhibitors and cell death</title><title>Cellular and molecular life sciences : CMLS</title><addtitle>Cell. Mol. Life Sci</addtitle><addtitle>Cell Mol Life Sci</addtitle><description>Histone deacetylases (HDACs) are a vast family of enzymes involved in chromatin remodeling and have crucial roles in numerous biological processes, largely through their repressive influence on transcription. In addition to modifying histones, HDACs also target many other non-histone protein substrates to regulate gene expression. Recently, HDACs have gained growing attention as HDAC-inhibiting compounds are being developed as promising cancer therapeutics. Histone deacetylase inhibitors (HDACi) have been shown to induce differentiation, cell cycle arrest, apoptosis, autophagy and necrosis in a variety of transformed cell lines. In this review, we mainly discuss how HDACi may elicit a therapeutic response to human cancers through different cell death pathways, in particular, apoptosis and autophagy.</description><subject>apoptosis</subject><subject>autophagy</subject><subject>Benzamides - chemistry</subject><subject>Benzamides - pharmacology</subject><subject>Benzamides - therapeutic use</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>cell cycle checkpoints</subject><subject>Cell death</subject><subject>Cell Death - drug effects</subject><subject>Cells</subject><subject>chromatin</subject><subject>Fatty Acids, Volatile - chemistry</subject><subject>Fatty Acids, Volatile - pharmacology</subject><subject>Fatty Acids, Volatile - therapeutic use</subject><subject>gene expression</subject><subject>histone deacetylase</subject><subject>Histone Deacetylase Inhibitors - chemistry</subject><subject>Histone Deacetylase Inhibitors - pharmacology</subject><subject>Histone Deacetylase Inhibitors - therapeutic use</subject><subject>Histone Deacetylases - chemistry</subject><subject>Histone Deacetylases - metabolism</subject><subject>histones</subject><subject>Humans</subject><subject>Hydroxamic Acids - chemistry</subject><subject>Hydroxamic Acids - pharmacology</subject><subject>Hydroxamic Acids - therapeutic use</subject><subject>Inhibitor drugs</subject><subject>Life Sciences</subject><subject>necrosis</subject><subject>neoplasms</subject><subject>Neoplasms - drug therapy</subject><subject>Peptides, Cyclic - chemistry</subject><subject>Peptides, Cyclic - pharmacology</subject><subject>Peptides, Cyclic - therapeutic use</subject><subject>Review</subject><subject>Signal Transduction - drug effects</subject><subject>therapeutics</subject><issn>1420-682X</issn><issn>1420-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kc1qGzEUhUVJqB23D9BNY-gmm2nu1f9sAsG0ScGQRWroTmjGGlthPHKkcSFvXw3jhCSLriS43zm6R4eQLwjfEUBdJgBAXQDyAqWQhfxApsgpFCUoPDnepaZ_JuQspYcMC03lRzKhXJcaNJuS4tanPnRuvna2dv1Ta5Ob-27rK9-HmOa2W89r17bDvN9-IqeNbZP7fDxnZPXzx-_FbbG8u_m1uF4WtWTQFwp1JWBtq4pKzUunBFJaO2DC1ppbp0vgTJWA4Cy3qlGN0JIrWQlWK6aRzcjV6Ls_VDu3rl3XR9uaffQ7G59MsN68nXR-azbhr-EcOYjB4OJoEMPjwaXe7HwactjOhUMyKKRE0HmRjH57hz6EQ-xyvIHiQkitVKZwpOoYUoqueVkGwQxlmLEMk8swQxlGZs3X1yleFM-_nwE6AimPuo2Lr57-j-v5KGpsMHYTfTKrewooM0lLZMj-AQQ3nAU</recordid><startdate>20141001</startdate><enddate>20141001</enddate><creator>Zhang, Jing</creator><creator>Zhong, Qing</creator><general>Springer-Verlag</general><general>Springer Basel</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20141001</creationdate><title>Histone deacetylase inhibitors and cell death</title><author>Zhang, Jing ; Zhong, Qing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c630t-718b50dabb26849e75122ce035ac84ae8904379010ea4a7f7f586476b53c73813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>apoptosis</topic><topic>autophagy</topic><topic>Benzamides - chemistry</topic><topic>Benzamides - pharmacology</topic><topic>Benzamides - therapeutic use</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Biology</topic><topic>cell cycle checkpoints</topic><topic>Cell death</topic><topic>Cell Death - drug effects</topic><topic>Cells</topic><topic>chromatin</topic><topic>Fatty Acids, Volatile - chemistry</topic><topic>Fatty Acids, Volatile - pharmacology</topic><topic>Fatty Acids, Volatile - therapeutic use</topic><topic>gene expression</topic><topic>histone deacetylase</topic><topic>Histone Deacetylase Inhibitors - chemistry</topic><topic>Histone Deacetylase Inhibitors - pharmacology</topic><topic>Histone Deacetylase Inhibitors - therapeutic use</topic><topic>Histone Deacetylases - chemistry</topic><topic>Histone Deacetylases - metabolism</topic><topic>histones</topic><topic>Humans</topic><topic>Hydroxamic Acids - chemistry</topic><topic>Hydroxamic Acids - pharmacology</topic><topic>Hydroxamic Acids - therapeutic use</topic><topic>Inhibitor drugs</topic><topic>Life Sciences</topic><topic>necrosis</topic><topic>neoplasms</topic><topic>Neoplasms - drug therapy</topic><topic>Peptides, Cyclic - chemistry</topic><topic>Peptides, Cyclic - pharmacology</topic><topic>Peptides, Cyclic - therapeutic use</topic><topic>Review</topic><topic>Signal Transduction - drug effects</topic><topic>therapeutics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Jing</creatorcontrib><creatorcontrib>Zhong, Qing</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cellular and molecular life sciences : CMLS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Jing</au><au>Zhong, Qing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histone deacetylase inhibitors and cell death</atitle><jtitle>Cellular and molecular life sciences : CMLS</jtitle><stitle>Cell. Mol. Life Sci</stitle><addtitle>Cell Mol Life Sci</addtitle><date>2014-10-01</date><risdate>2014</risdate><volume>71</volume><issue>20</issue><spage>3885</spage><epage>3901</epage><pages>3885-3901</pages><issn>1420-682X</issn><eissn>1420-9071</eissn><abstract>Histone deacetylases (HDACs) are a vast family of enzymes involved in chromatin remodeling and have crucial roles in numerous biological processes, largely through their repressive influence on transcription. In addition to modifying histones, HDACs also target many other non-histone protein substrates to regulate gene expression. Recently, HDACs have gained growing attention as HDAC-inhibiting compounds are being developed as promising cancer therapeutics. Histone deacetylase inhibitors (HDACi) have been shown to induce differentiation, cell cycle arrest, apoptosis, autophagy and necrosis in a variety of transformed cell lines. In this review, we mainly discuss how HDACi may elicit a therapeutic response to human cancers through different cell death pathways, in particular, apoptosis and autophagy.</abstract><cop>Basel</cop><pub>Springer-Verlag</pub><pmid>24898083</pmid><doi>10.1007/s00018-014-1656-6</doi><tpages>17</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | apoptosis autophagy Benzamides - chemistry Benzamides - pharmacology Benzamides - therapeutic use Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology cell cycle checkpoints Cell death Cell Death - drug effects Cells chromatin Fatty Acids, Volatile - chemistry Fatty Acids, Volatile - pharmacology Fatty Acids, Volatile - therapeutic use gene expression histone deacetylase Histone Deacetylase Inhibitors - chemistry Histone Deacetylase Inhibitors - pharmacology Histone Deacetylase Inhibitors - therapeutic use Histone Deacetylases - chemistry Histone Deacetylases - metabolism histones Humans Hydroxamic Acids - chemistry Hydroxamic Acids - pharmacology Hydroxamic Acids - therapeutic use Inhibitor drugs Life Sciences necrosis neoplasms Neoplasms - drug therapy Peptides, Cyclic - chemistry Peptides, Cyclic - pharmacology Peptides, Cyclic - therapeutic use Review Signal Transduction - drug effects therapeutics |
| title | Histone deacetylase inhibitors and cell death |
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