Gastrointestinal Inhibition of Sodium-Hydrogen Exchanger 3 Reduces Phosphorus Absorption and Protects against Vascular Calcification in CKD

In CKD, phosphate retention arising from diminished GFR is a key early step in a pathologic cascade leading to hyperthyroidism, metabolic bone disease, vascular calcification, and cardiovascular mortality. Tenapanor, a minimally systemically available inhibitor of the intestinal sodium-hydrogen exch...

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Veröffentlicht in:	Journal of the American Society of Nephrology 2015-05, Vol.26 (5), p.1138-1149
Hauptverfasser:	Labonté, Eric D, Carreras, Christopher W, Leadbetter, Michael R, Kozuka, Kenji, Kohler, Jill, Koo-McCoy, Samantha, He, Limin, Dy, Edward, Black, Deborah, Zhong, Ziyang, Langsetmo, Ingrid, Spencer, Andrew G, Bell, Noah, Deshpande, Desiree, Navre, Marc, Lewis, Jason G, Jacobs, Jeffrey W, Charmot, Dominique
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic Research Calcinosis - etiology Calcinosis - prevention & control Disease Models, Animal Gastrointestinal Tract - drug effects Gastrointestinal Tract - metabolism Isoquinolines - pharmacology Isoquinolines - therapeutic use Male Phosphorus - urine Random Allocation Rats, Sprague-Dawley Renal Insufficiency, Chronic - complications Renal Insufficiency, Chronic - drug therapy Renal Insufficiency, Chronic - metabolism Sodium - metabolism Sodium-Hydrogen Exchanger 3 Sodium-Hydrogen Exchangers - antagonists & inhibitors Sodium-Hydrogen Exchangers - metabolism Sulfonamides - pharmacology Sulfonamides - therapeutic use
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