KITENIN promotes glioma invasiveness and progression, associated with the induction of EMT and stemness markers

KITENIN (KAI1 COOH-terminal interacting tetraspanin) promotes tumor invasion and metastasis in various cancers. This study assessed the association between KITENIN expression and advanced glioma grade in patients. In vitro assays revealed that KITENIN knockdown inhibited the invasion and migration o...

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Veröffentlicht in:	Oncotarget 2015-02, Vol.6 (5), p.3240-3253
Hauptverfasser:	Lee, Kyung-Hwa, Ahn, Eun-Jung, Oh, Se-Jeong, Kim, Ok, Joo, Young-Eun, Bae, Jeong-A, Yoon, Somy, Ryu, Hyang-Hwa, Jung, Shin, Kim, Kyung-Keun, Lee, Jae-Hyuk, Moon, Kyung-Sub
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Brain Neoplasms - genetics Brain Neoplasms - metabolism Brain Neoplasms - mortality Brain Neoplasms - pathology Brain Neoplasms - surgery Carrier Proteins - genetics Carrier Proteins - metabolism Cell Line, Tumor Cell Movement Epithelial-Mesenchymal Transition Female Glioma - genetics Glioma - metabolism Glioma - mortality Glioma - pathology Glioma - surgery Humans Male Membrane Proteins - genetics Membrane Proteins - metabolism Mice, Inbred BALB C Mice, Inbred C57BL Mice, Nude Middle Aged Neoplasm Invasiveness Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Research Paper RNA Interference Signal Transduction Time Factors Transfection Up-Regulation
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