Effect of urban vs. rural residence on the association between atopy and wheeze in Latin America: findings from a case-control analysis
Summary Background The association between atopy and asthma is attenuated in non‐affluent populations, an effect that may be explained by childhood infections such as geohelminths. Objective To investigate the association between atopy and wheeze in schoolchildren living in urban and rural areas of...
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| Veröffentlicht in: | Clinical and experimental allergy 2015-02, Vol.45 (2), p.438-447 |
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| creator | Endara, P. Vaca, M. Platts-Mills, T. A. E. Workman, L. Chico, M. E. Barreto, M. L. Rodrigues, L. C. Cooper, P. J. |
| description | Summary
Background
The association between atopy and asthma is attenuated in non‐affluent populations, an effect that may be explained by childhood infections such as geohelminths.
Objective
To investigate the association between atopy and wheeze in schoolchildren living in urban and rural areas of Ecuador and examine the effects of geohelminths on this association.
Methods
We performed nested case–control studies among comparable populations of schoolchildren living in rural communities and urban neighbourhoods in the Province of Esmeraldas, Ecuador. We detected geohelminths in stool samples, measured recent wheeze and environmental exposures by parental questionnaire, and atopy by specific IgE (sIgE) and skin prick test (SPT) reactivity to aeroallergens.
Results
Atopy, particularly sIgE to house dust mite (HDM), was more strongly associated with recent wheeze in urban than rural schoolchildren: (urban, adj. OR 5.19, 95% CI 3.37–8.00, P |
| doi_str_mv | 10.1111/cea.12399 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4413357</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3569501991</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5479-c5fa7467f9a69d0ac94a2cdcc607d9b9b4c91a75403384e0fce69df914cd416f3</originalsourceid><addsrcrecordid>eNp1kcFu1DAQhi0EokvhwAsgS5w4ZOskThxzQFqWpSBW5QLiaE2ccdclay920mX7An1tDGlXcGAOtqz5_t8z-gl5nrN5nupMI8zzopTyAZnlZV1lRaqHZMZkxTPRSH5CnsR4xRgrK9k8JidFVTBWNGJGblfGoB6oN3QMLTh6Hec0jAF6GjDaDp1G6h0dNkghRq8tDDa9Wxz2iI7C4HcHCq6j-w3iDVLr6Dohji62GKyG19RY11l3GakJfkuBaoiYae-G4PukhP4QbXxKHhnoIz67u0_J1_erL8sP2frz-cflYp3piguZTgOC18JIqGXHQEsOhe60rpnoZCtbrmUOouKsLBuOzGhMnJE51x3Pa1OekjeT725st9hpTGNAr3bBbiEclAer_u04u1GX_lpxnpdlJZLByzuD4H-MGAd15ceQtogqr3lTMDlRryZKBx9jQHP8IWfqd2YqZab-ZJbYF3-PdCTvQ0rA2QTsbY-H_zup5Wpxb5lNChsH_HlUQPiualGKSn27OFef3tUXoi7eKlb-AgN9shA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1648209357</pqid></control><display><type>article</type><title>Effect of urban vs. rural residence on the association between atopy and wheeze in Latin America: findings from a case-control analysis</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Endara, P. ; Vaca, M. ; Platts-Mills, T. A. E. ; Workman, L. ; Chico, M. E. ; Barreto, M. L. ; Rodrigues, L. C. ; Cooper, P. J.</creator><creatorcontrib>Endara, P. ; Vaca, M. ; Platts-Mills, T. A. E. ; Workman, L. ; Chico, M. E. ; Barreto, M. L. ; Rodrigues, L. C. ; Cooper, P. J.</creatorcontrib><description>Summary
Background
The association between atopy and asthma is attenuated in non‐affluent populations, an effect that may be explained by childhood infections such as geohelminths.
Objective
To investigate the association between atopy and wheeze in schoolchildren living in urban and rural areas of Ecuador and examine the effects of geohelminths on this association.
Methods
We performed nested case–control studies among comparable populations of schoolchildren living in rural communities and urban neighbourhoods in the Province of Esmeraldas, Ecuador. We detected geohelminths in stool samples, measured recent wheeze and environmental exposures by parental questionnaire, and atopy by specific IgE (sIgE) and skin prick test (SPT) reactivity to aeroallergens.
Results
Atopy, particularly sIgE to house dust mite (HDM), was more strongly associated with recent wheeze in urban than rural schoolchildren: (urban, adj. OR 5.19, 95% CI 3.37–8.00, P < 0.0001; rural, adj. OR 1.81, 95%CI 1.09–2.99, P = 0.02; interaction, P < 0.001). The population fractions of wheeze attributable to atopy were approximately two‐fold greater in urban schoolchildren: SPT to any allergen (urban 23.5% vs. rural 10.1%), SPT to HDM (urban 18.5% vs. rural 9.6%), and anti‐HDM IgE (urban 26.5% vs. rural 10.5%), while anti‐Ascaris IgE was related to wheeze in a high proportion of rural (49.7%) and urban (35.4%) children. The association between atopy and recent wheeze was attenuated by markers of geohelminth infections.
Conclusions
Our data suggest that urban residence modifies the association between HDM atopy and recent wheeze, and this effect is explained partly by geohelminth infections.</description><identifier>ISSN: 0954-7894</identifier><identifier>EISSN: 1365-2222</identifier><identifier>DOI: 10.1111/cea.12399</identifier><identifier>PMID: 25200287</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Allergens - immunology ; Animals ; atopy ; Case-Control Studies ; Child ; Cross-Sectional Studies ; Environmental Exposure - adverse effects ; Female ; geohelminths ; house dust mite ; Humans ; Hypersensitivity, Immediate - epidemiology ; Hypersensitivity, Immediate - immunology ; Immunoglobulin E - blood ; Immunoglobulin E - immunology ; Latin America ; Latin America - epidemiology ; Male ; Original ; Respiratory Sounds - immunology ; Risk Factors ; rural ; Rural Population ; Skin Tests ; Surveys and Questionnaires ; tropics ; urban ; Urban Population ; wheeze ; Young Adult</subject><ispartof>Clinical and experimental allergy, 2015-02, Vol.45 (2), p.438-447</ispartof><rights>2014 The Authors. Published by John Wiley & Sons Ltd.</rights><rights>2014 The Authors. Clinical & Experimental Allergy Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2015 John Wiley & Sons Ltd</rights><rights>2014 The Authors. Published by John Wiley & Sons Ltd. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5479-c5fa7467f9a69d0ac94a2cdcc607d9b9b4c91a75403384e0fce69df914cd416f3</citedby><cites>FETCH-LOGICAL-c5479-c5fa7467f9a69d0ac94a2cdcc607d9b9b4c91a75403384e0fce69df914cd416f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcea.12399$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcea.12399$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25200287$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Endara, P.</creatorcontrib><creatorcontrib>Vaca, M.</creatorcontrib><creatorcontrib>Platts-Mills, T. A. E.</creatorcontrib><creatorcontrib>Workman, L.</creatorcontrib><creatorcontrib>Chico, M. E.</creatorcontrib><creatorcontrib>Barreto, M. L.</creatorcontrib><creatorcontrib>Rodrigues, L. C.</creatorcontrib><creatorcontrib>Cooper, P. J.</creatorcontrib><title>Effect of urban vs. rural residence on the association between atopy and wheeze in Latin America: findings from a case-control analysis</title><title>Clinical and experimental allergy</title><addtitle>Clin Exp Allergy</addtitle><description>Summary
Background
The association between atopy and asthma is attenuated in non‐affluent populations, an effect that may be explained by childhood infections such as geohelminths.
Objective
To investigate the association between atopy and wheeze in schoolchildren living in urban and rural areas of Ecuador and examine the effects of geohelminths on this association.
Methods
We performed nested case–control studies among comparable populations of schoolchildren living in rural communities and urban neighbourhoods in the Province of Esmeraldas, Ecuador. We detected geohelminths in stool samples, measured recent wheeze and environmental exposures by parental questionnaire, and atopy by specific IgE (sIgE) and skin prick test (SPT) reactivity to aeroallergens.
Results
Atopy, particularly sIgE to house dust mite (HDM), was more strongly associated with recent wheeze in urban than rural schoolchildren: (urban, adj. OR 5.19, 95% CI 3.37–8.00, P < 0.0001; rural, adj. OR 1.81, 95%CI 1.09–2.99, P = 0.02; interaction, P < 0.001). The population fractions of wheeze attributable to atopy were approximately two‐fold greater in urban schoolchildren: SPT to any allergen (urban 23.5% vs. rural 10.1%), SPT to HDM (urban 18.5% vs. rural 9.6%), and anti‐HDM IgE (urban 26.5% vs. rural 10.5%), while anti‐Ascaris IgE was related to wheeze in a high proportion of rural (49.7%) and urban (35.4%) children. The association between atopy and recent wheeze was attenuated by markers of geohelminth infections.
Conclusions
Our data suggest that urban residence modifies the association between HDM atopy and recent wheeze, and this effect is explained partly by geohelminth infections.</description><subject>Adolescent</subject><subject>Allergens - immunology</subject><subject>Animals</subject><subject>atopy</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Cross-Sectional Studies</subject><subject>Environmental Exposure - adverse effects</subject><subject>Female</subject><subject>geohelminths</subject><subject>house dust mite</subject><subject>Humans</subject><subject>Hypersensitivity, Immediate - epidemiology</subject><subject>Hypersensitivity, Immediate - immunology</subject><subject>Immunoglobulin E - blood</subject><subject>Immunoglobulin E - immunology</subject><subject>Latin America</subject><subject>Latin America - epidemiology</subject><subject>Male</subject><subject>Original</subject><subject>Respiratory Sounds - immunology</subject><subject>Risk Factors</subject><subject>rural</subject><subject>Rural Population</subject><subject>Skin Tests</subject><subject>Surveys and Questionnaires</subject><subject>tropics</subject><subject>urban</subject><subject>Urban Population</subject><subject>wheeze</subject><subject>Young Adult</subject><issn>0954-7894</issn><issn>1365-2222</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp1kcFu1DAQhi0EokvhwAsgS5w4ZOskThxzQFqWpSBW5QLiaE2ccdclay920mX7An1tDGlXcGAOtqz5_t8z-gl5nrN5nupMI8zzopTyAZnlZV1lRaqHZMZkxTPRSH5CnsR4xRgrK9k8JidFVTBWNGJGblfGoB6oN3QMLTh6Hec0jAF6GjDaDp1G6h0dNkghRq8tDDa9Wxz2iI7C4HcHCq6j-w3iDVLr6Dohji62GKyG19RY11l3GakJfkuBaoiYae-G4PukhP4QbXxKHhnoIz67u0_J1_erL8sP2frz-cflYp3piguZTgOC18JIqGXHQEsOhe60rpnoZCtbrmUOouKsLBuOzGhMnJE51x3Pa1OekjeT725st9hpTGNAr3bBbiEclAer_u04u1GX_lpxnpdlJZLByzuD4H-MGAd15ceQtogqr3lTMDlRryZKBx9jQHP8IWfqd2YqZab-ZJbYF3-PdCTvQ0rA2QTsbY-H_zup5Wpxb5lNChsH_HlUQPiualGKSn27OFef3tUXoi7eKlb-AgN9shA</recordid><startdate>201502</startdate><enddate>201502</enddate><creator>Endara, P.</creator><creator>Vaca, M.</creator><creator>Platts-Mills, T. A. E.</creator><creator>Workman, L.</creator><creator>Chico, M. E.</creator><creator>Barreto, M. L.</creator><creator>Rodrigues, L. C.</creator><creator>Cooper, P. J.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><general>BlackWell Publishing Ltd</general><scope>BSCLL</scope><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>5PM</scope></search><sort><creationdate>201502</creationdate><title>Effect of urban vs. rural residence on the association between atopy and wheeze in Latin America: findings from a case-control analysis</title><author>Endara, P. ; Vaca, M. ; Platts-Mills, T. A. E. ; Workman, L. ; Chico, M. E. ; Barreto, M. L. ; Rodrigues, L. C. ; Cooper, P. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5479-c5fa7467f9a69d0ac94a2cdcc607d9b9b4c91a75403384e0fce69df914cd416f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Allergens - immunology</topic><topic>Animals</topic><topic>atopy</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Cross-Sectional Studies</topic><topic>Environmental Exposure - adverse effects</topic><topic>Female</topic><topic>geohelminths</topic><topic>house dust mite</topic><topic>Humans</topic><topic>Hypersensitivity, Immediate - epidemiology</topic><topic>Hypersensitivity, Immediate - immunology</topic><topic>Immunoglobulin E - blood</topic><topic>Immunoglobulin E - immunology</topic><topic>Latin America</topic><topic>Latin America - epidemiology</topic><topic>Male</topic><topic>Original</topic><topic>Respiratory Sounds - immunology</topic><topic>Risk Factors</topic><topic>rural</topic><topic>Rural Population</topic><topic>Skin Tests</topic><topic>Surveys and Questionnaires</topic><topic>tropics</topic><topic>urban</topic><topic>Urban Population</topic><topic>wheeze</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Endara, P.</creatorcontrib><creatorcontrib>Vaca, M.</creatorcontrib><creatorcontrib>Platts-Mills, T. A. E.</creatorcontrib><creatorcontrib>Workman, L.</creatorcontrib><creatorcontrib>Chico, M. E.</creatorcontrib><creatorcontrib>Barreto, M. L.</creatorcontrib><creatorcontrib>Rodrigues, L. C.</creatorcontrib><creatorcontrib>Cooper, P. J.</creatorcontrib><collection>Istex</collection><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical and experimental allergy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Endara, P.</au><au>Vaca, M.</au><au>Platts-Mills, T. A. E.</au><au>Workman, L.</au><au>Chico, M. E.</au><au>Barreto, M. L.</au><au>Rodrigues, L. C.</au><au>Cooper, P. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of urban vs. rural residence on the association between atopy and wheeze in Latin America: findings from a case-control analysis</atitle><jtitle>Clinical and experimental allergy</jtitle><addtitle>Clin Exp Allergy</addtitle><date>2015-02</date><risdate>2015</risdate><volume>45</volume><issue>2</issue><spage>438</spage><epage>447</epage><pages>438-447</pages><issn>0954-7894</issn><eissn>1365-2222</eissn><abstract>Summary
Background
The association between atopy and asthma is attenuated in non‐affluent populations, an effect that may be explained by childhood infections such as geohelminths.
Objective
To investigate the association between atopy and wheeze in schoolchildren living in urban and rural areas of Ecuador and examine the effects of geohelminths on this association.
Methods
We performed nested case–control studies among comparable populations of schoolchildren living in rural communities and urban neighbourhoods in the Province of Esmeraldas, Ecuador. We detected geohelminths in stool samples, measured recent wheeze and environmental exposures by parental questionnaire, and atopy by specific IgE (sIgE) and skin prick test (SPT) reactivity to aeroallergens.
Results
Atopy, particularly sIgE to house dust mite (HDM), was more strongly associated with recent wheeze in urban than rural schoolchildren: (urban, adj. OR 5.19, 95% CI 3.37–8.00, P < 0.0001; rural, adj. OR 1.81, 95%CI 1.09–2.99, P = 0.02; interaction, P < 0.001). The population fractions of wheeze attributable to atopy were approximately two‐fold greater in urban schoolchildren: SPT to any allergen (urban 23.5% vs. rural 10.1%), SPT to HDM (urban 18.5% vs. rural 9.6%), and anti‐HDM IgE (urban 26.5% vs. rural 10.5%), while anti‐Ascaris IgE was related to wheeze in a high proportion of rural (49.7%) and urban (35.4%) children. The association between atopy and recent wheeze was attenuated by markers of geohelminth infections.
Conclusions
Our data suggest that urban residence modifies the association between HDM atopy and recent wheeze, and this effect is explained partly by geohelminth infections.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>25200287</pmid><doi>10.1111/cea.12399</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0954-7894 |
| ispartof | Clinical and experimental allergy, 2015-02, Vol.45 (2), p.438-447 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Allergens - immunology Animals atopy Case-Control Studies Child Cross-Sectional Studies Environmental Exposure - adverse effects Female geohelminths house dust mite Humans Hypersensitivity, Immediate - epidemiology Hypersensitivity, Immediate - immunology Immunoglobulin E - blood Immunoglobulin E - immunology Latin America Latin America - epidemiology Male Original Respiratory Sounds - immunology Risk Factors rural Rural Population Skin Tests Surveys and Questionnaires tropics urban Urban Population wheeze Young Adult |
| title | Effect of urban vs. rural residence on the association between atopy and wheeze in Latin America: findings from a case-control analysis |
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