Influence of hemodynamics and intra-operative hydration on biochemical outcome of renal transplant recipients
Early graft function is crucial for successful kidney transplantation. The aim of our study was to evaluate the effect of intra-operative central venous pressure (CVP) and mean arterial pressure (MAP) on early graft function and biochemical outcome. This was a retrospective study carried out on pati...
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| Veröffentlicht in: | Journal of anaesthesiology, clinical pharmacology clinical pharmacology, 2015-04, Vol.31 (2), p.174-179 |
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| creator | Aulakh, Navpreet Kaur Garg, Kamakshi Bose, Abhishek Aulakh, Baldev Singh Chahal, Harmandeep Singh Aulakh, Gurmehar Singh |
| description | Early graft function is crucial for successful kidney transplantation. The aim of our study was to evaluate the effect of intra-operative central venous pressure (CVP) and mean arterial pressure (MAP) on early graft function and biochemical outcome.
This was a retrospective study carried out on patients undergoing renal transplant only from live-related donors between March 2011 and May 2013. We mainly divided the patients into two groups based on CVP and mean MAP. One group had CVP more than 12 and other with CVP 100 mmHg and other with mean MAP of 95 mmHg with good perioperative fluid hydration is associated with good early graft function. |
| doi_str_mv | 10.4103/0970-9185.155144 |
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This was a retrospective study carried out on patients undergoing renal transplant only from live-related donors between March 2011 and May 2013. We mainly divided the patients into two groups based on CVP and mean MAP. One group had CVP more than 12 and other with CVP <12 mmHg at the time of declamping. Further one group was with mean MAP >100 mmHg and other with mean MAP of <100 mmHg. The graft outcome of genetically related and genetically unrelated donors was also evaluated in early postoperative period. The trend in fall of serum creatinine was studied during the first five post-operative days. The effect of age, dry weight, sex, relation with donor and intraoperative factors like MAP and CVP on early graft function were analysed. Correlation analysis, analysis of variance test (ANOVA) and multivariate analysis technique were used in this study for statistical computation.
The mean CVP at the time of declamping was 13.91 mmHg. The minimum CVP was 6 mmHg in one patient who had ischemic heart disease with low ejection fraction. All 5 days mean serum creatinine values were comparable in two groups on 1(st), 2(nd), 3(rd) and 4(th) postoperative days. The mean MAP at the time of declamping was 111.22 mmHg. Mean MAP varied from a minimum of 95 mmHg to maximum of 131 mmHg. There was no significant difference in two groups on 1(st), 2(nd), 3(rd), 4(th) and 5(th) postoperative days.
A CVP around 12 mmHg and mean MAP >95 mmHg with good perioperative fluid hydration is associated with good early graft function.</description><identifier>ISSN: 0970-9185</identifier><identifier>EISSN: 2231-2730</identifier><identifier>DOI: 10.4103/0970-9185.155144</identifier><identifier>PMID: 25948896</identifier><language>eng</language><publisher>India: Medknow Publications and Media Pvt. Ltd</publisher><subject>Care and treatment ; Chronic kidney failure ; Diagnosis ; Health aspects ; Kidney transplantation ; Organ transplant recipients ; Original ; Venous pressure</subject><ispartof>Journal of anaesthesiology, clinical pharmacology, 2015-04, Vol.31 (2), p.174-179</ispartof><rights>COPYRIGHT 2015 Medknow Publications and Media Pvt. Ltd.</rights><rights>Copyright: © Journal of Anaesthesiology Clinical Pharmacology 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4094-f0b28179c801150ee7308446ee906216717cbfa46cb99c6d19bfd07060c90aeb3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411829/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411829/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,862,883,27907,27908,53774,53776</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25948896$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aulakh, Navpreet Kaur</creatorcontrib><creatorcontrib>Garg, Kamakshi</creatorcontrib><creatorcontrib>Bose, Abhishek</creatorcontrib><creatorcontrib>Aulakh, Baldev Singh</creatorcontrib><creatorcontrib>Chahal, Harmandeep Singh</creatorcontrib><creatorcontrib>Aulakh, Gurmehar Singh</creatorcontrib><title>Influence of hemodynamics and intra-operative hydration on biochemical outcome of renal transplant recipients</title><title>Journal of anaesthesiology, clinical pharmacology</title><addtitle>J Anaesthesiol Clin Pharmacol</addtitle><description>Early graft function is crucial for successful kidney transplantation. The aim of our study was to evaluate the effect of intra-operative central venous pressure (CVP) and mean arterial pressure (MAP) on early graft function and biochemical outcome.
This was a retrospective study carried out on patients undergoing renal transplant only from live-related donors between March 2011 and May 2013. We mainly divided the patients into two groups based on CVP and mean MAP. One group had CVP more than 12 and other with CVP <12 mmHg at the time of declamping. Further one group was with mean MAP >100 mmHg and other with mean MAP of <100 mmHg. The graft outcome of genetically related and genetically unrelated donors was also evaluated in early postoperative period. The trend in fall of serum creatinine was studied during the first five post-operative days. The effect of age, dry weight, sex, relation with donor and intraoperative factors like MAP and CVP on early graft function were analysed. Correlation analysis, analysis of variance test (ANOVA) and multivariate analysis technique were used in this study for statistical computation.
The mean CVP at the time of declamping was 13.91 mmHg. The minimum CVP was 6 mmHg in one patient who had ischemic heart disease with low ejection fraction. All 5 days mean serum creatinine values were comparable in two groups on 1(st), 2(nd), 3(rd) and 4(th) postoperative days. The mean MAP at the time of declamping was 111.22 mmHg. Mean MAP varied from a minimum of 95 mmHg to maximum of 131 mmHg. There was no significant difference in two groups on 1(st), 2(nd), 3(rd), 4(th) and 5(th) postoperative days.
A CVP around 12 mmHg and mean MAP >95 mmHg with good perioperative fluid hydration is associated with good early graft function.</description><subject>Care and treatment</subject><subject>Chronic kidney failure</subject><subject>Diagnosis</subject><subject>Health aspects</subject><subject>Kidney transplantation</subject><subject>Organ transplant recipients</subject><subject>Original</subject><subject>Venous pressure</subject><issn>0970-9185</issn><issn>2231-2730</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNptUk1r3DAQFaWl2aa991QMhdKLtyNbtqRLIYR-BAK9tGchy-NYRZZcyw7sv4_UTZcsFAk0zLz30BseIW8p7BmF-hNIDqWkotnTpqGMPSO7qqppWfEanpPdaXxBXsX4G6ABXjUvyUXVSCaEbHdkuvGD29AbLMJQjDiF_uD1ZE0stO8L69dFl2HGRa_2Hovx0Ocq-CLdzgaTGNZoV4RtNWH6K7KgT43E83F22q-pYexs0a_xNXkxaBfxzeN7SX59_fLz-nt5--PbzfXVbWkYSFYO0FWCcmkEUNoAYrIjGGsRJbQVbTnlphs0a00npWl7KruhBw4tGAkau_qSfD7qzls3YW8w23BqXuykl4MK2qrzibejugv3ijFKRSWTwMdHgSX82TCuarLRoEt-MGxR0TZ9TXDGM_T9EXqnHSrrh5AUTYarq6SWxISEhNr_B5VOnxcYPA429c8IH54QRtRuHWNwW15-PAfCEWiWEOOCw8kmBZVTonIMVI6BOqYkUd49Xc-J8C8W9QNu07fx</recordid><startdate>20150401</startdate><enddate>20150401</enddate><creator>Aulakh, Navpreet Kaur</creator><creator>Garg, Kamakshi</creator><creator>Bose, Abhishek</creator><creator>Aulakh, Baldev Singh</creator><creator>Chahal, Harmandeep Singh</creator><creator>Aulakh, Gurmehar Singh</creator><general>Medknow Publications and Media Pvt. Ltd</general><general>Medknow Publications & Media Pvt Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150401</creationdate><title>Influence of hemodynamics and intra-operative hydration on biochemical outcome of renal transplant recipients</title><author>Aulakh, Navpreet Kaur ; Garg, Kamakshi ; Bose, Abhishek ; Aulakh, Baldev Singh ; Chahal, Harmandeep Singh ; Aulakh, Gurmehar Singh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4094-f0b28179c801150ee7308446ee906216717cbfa46cb99c6d19bfd07060c90aeb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Care and treatment</topic><topic>Chronic kidney failure</topic><topic>Diagnosis</topic><topic>Health aspects</topic><topic>Kidney transplantation</topic><topic>Organ transplant recipients</topic><topic>Original</topic><topic>Venous pressure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aulakh, Navpreet Kaur</creatorcontrib><creatorcontrib>Garg, Kamakshi</creatorcontrib><creatorcontrib>Bose, Abhishek</creatorcontrib><creatorcontrib>Aulakh, Baldev Singh</creatorcontrib><creatorcontrib>Chahal, Harmandeep Singh</creatorcontrib><creatorcontrib>Aulakh, Gurmehar Singh</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of anaesthesiology, clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aulakh, Navpreet Kaur</au><au>Garg, Kamakshi</au><au>Bose, Abhishek</au><au>Aulakh, Baldev Singh</au><au>Chahal, Harmandeep Singh</au><au>Aulakh, Gurmehar Singh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of hemodynamics and intra-operative hydration on biochemical outcome of renal transplant recipients</atitle><jtitle>Journal of anaesthesiology, clinical pharmacology</jtitle><addtitle>J Anaesthesiol Clin Pharmacol</addtitle><date>2015-04-01</date><risdate>2015</risdate><volume>31</volume><issue>2</issue><spage>174</spage><epage>179</epage><pages>174-179</pages><issn>0970-9185</issn><eissn>2231-2730</eissn><abstract>Early graft function is crucial for successful kidney transplantation. The aim of our study was to evaluate the effect of intra-operative central venous pressure (CVP) and mean arterial pressure (MAP) on early graft function and biochemical outcome.
This was a retrospective study carried out on patients undergoing renal transplant only from live-related donors between March 2011 and May 2013. We mainly divided the patients into two groups based on CVP and mean MAP. One group had CVP more than 12 and other with CVP <12 mmHg at the time of declamping. Further one group was with mean MAP >100 mmHg and other with mean MAP of <100 mmHg. The graft outcome of genetically related and genetically unrelated donors was also evaluated in early postoperative period. The trend in fall of serum creatinine was studied during the first five post-operative days. The effect of age, dry weight, sex, relation with donor and intraoperative factors like MAP and CVP on early graft function were analysed. Correlation analysis, analysis of variance test (ANOVA) and multivariate analysis technique were used in this study for statistical computation.
The mean CVP at the time of declamping was 13.91 mmHg. The minimum CVP was 6 mmHg in one patient who had ischemic heart disease with low ejection fraction. All 5 days mean serum creatinine values were comparable in two groups on 1(st), 2(nd), 3(rd) and 4(th) postoperative days. The mean MAP at the time of declamping was 111.22 mmHg. Mean MAP varied from a minimum of 95 mmHg to maximum of 131 mmHg. There was no significant difference in two groups on 1(st), 2(nd), 3(rd), 4(th) and 5(th) postoperative days.
A CVP around 12 mmHg and mean MAP >95 mmHg with good perioperative fluid hydration is associated with good early graft function.</abstract><cop>India</cop><pub>Medknow Publications and Media Pvt. Ltd</pub><pmid>25948896</pmid><doi>10.4103/0970-9185.155144</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Care and treatment Chronic kidney failure Diagnosis Health aspects Kidney transplantation Organ transplant recipients Original Venous pressure |
| title | Influence of hemodynamics and intra-operative hydration on biochemical outcome of renal transplant recipients |
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