A Bayesian framework for de novo mutation calling in parents-offspring trios

Spontaneous (de novo) mutations play an important role in the disease etiology of a range of complex diseases. Identifying de novo mutations (DNMs) in sporadic cases provides an effective strategy to find genes or genomic regions implicated in the genetics of disease. High-throughput next-generation...

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Veröffentlicht in:	Bioinformatics 2015-05, Vol.31 (9), p.1375-1381
Hauptverfasser:	Wei, Qiang, Zhan, Xiaowei, Zhong, Xue, Liu, Yongzhuang, Han, Yujun, Chen, Wei, Li, Bingshan
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Alignment Bayes Theorem Bayesian analysis Bioinformatics DNA Mutational Analysis - methods Filtering Filtration Gene sequencing Genomics - methods High-Throughput Nucleotide Sequencing - methods Humans Mutations Original Papers Sequence Alignment Source code
Online-Zugang:	Volltext
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