Celastrol, a Chinese herbal compound, controls autoimmune inflammation by altering the balance of pathogenic and regulatory T cells in the target organ

Abstract Inflammation is an integral component of autoimmune arthritis. The balance of pathogenic T helper 17 (Th17) and protective T regulatory (Treg) cells can influence disease severity, and its resetting offers an attractive approach to control autoimmunity. We determined the frequency of Th17 a...

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.) Fla.), 2015-04, Vol.157 (2), p.228-238
Hauptverfasser:	Astry, Brian, Venkatesha, Shivaprasad H, Laurence, Arian, Christensen-Quick, Aaron, Garzino-demo, Alfredo, Frieman, Matthew B, O'Shea, John J, Moudgil, Kamal D
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Arthritis, Experimental - immunology Arthritis, Rheumatoid Autoimmune Diseases - immunology Celastrol Celastrus Cell Differentiation - drug effects Chemotaxis - drug effects Chemotaxis - immunology Chinese medicine Disease Models, Animal Drugs, Chinese Herbal - pharmacology Experimental arthritis Immune regulation Inflammation - immunology Rats Rheumatoid arthritis T helper 17 cells T regulatory cells T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology Th17 Cells - drug effects Th17 Cells - immunology Triterpenes - pharmacology
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