Excision of Hypoxanthine from DNA Containing dIMP Residues by the Escherichia coli, Yeast, Rat, and Human Alkylpurine DNA Glycosylases

The deamination of adenine residues in DNA generates hypoxanthine, which is mutagenic since it gives rise to an A·T to G·C transition. Hypoxanthine is removed by hypoxanthine DNA glycosylase activity present in Escherichia coli and mammalian cells. Using polydeoxyribonucleotides or double-stranded s...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1994-06, Vol.91 (13), p.5873-5877
Hauptverfasser:	Saparbaev, Murat, Laval, Jacques
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Animals Bacteria Base Composition Base Sequence Cellular biology Chemical bases Chromatography, High Pressure Liquid Deoxyribonucleic acid DNA DNA - chemistry DNA - metabolism DNA Glycosylases Enzymes Escherichia coli Escherichia coli - drug effects Escherichia coli - enzymology Escherichia coli - genetics Gels Genes, Bacterial Humans Hypoxanthine Hypoxanthines - metabolism Hypoxia Kinetics Methylnitronitrosoguanidine - toxicity Molecular Sequence Data N-Glycosyl Hydrolases - genetics N-Glycosyl Hydrolases - isolation & purification N-Glycosyl Hydrolases - metabolism Nucleic acids Oligodeoxyribonucleotides - chemical synthesis Oligodeoxyribonucleotides - chemistry Oligonucleotides Organophosphorus Compounds Plasmids Rats Saccharomyces cerevisiae Saccharomyces cerevisiae - enzymology Substrate Specificity Yeasts
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