MEF2B-Nox1 Signaling Is Critical for Stretch-Induced Phenotypic Modulation of Vascular Smooth Muscle Cells

OBJECTIVE—Blood vessel hemodynamics have profound influences on function and structure of vascular cells. One of the main mechanical forces influencing vascular smooth muscle cells (VSMC) is cyclic stretch (CS). Increased CS stimulates reactive oxygen species (ROS) production in VSMC, leading to the...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2015-02, Vol.35 (2), p.430-438
Hauptverfasser:	Rodríguez, Andrés I, Csányi, Gábor, Ranayhossaini, Daniel J, Feck, Douglas M, Blose, Kory J, Assatourian, Lillian, Vorp, David A, Pagano, Patrick J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers - metabolism Calcium-Binding Proteins - metabolism Calponins Cell Movement Cells, Cultured Cytoskeletal Proteins - metabolism Enzyme Inhibitors - pharmacology Matrix Metalloproteinase 9 - metabolism Mechanotransduction, Cellular - drug effects MEF2 Transcription Factors - genetics MEF2 Transcription Factors - metabolism Microfilament Proteins - metabolism Muscle Proteins - metabolism Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism NADH, NADPH Oxidoreductases - antagonists & inhibitors NADH, NADPH Oxidoreductases - genetics NADH, NADPH Oxidoreductases - metabolism NADPH Oxidase 1 Osteopontin - metabolism Phenotype Pressoreceptors - metabolism Rats Reactive Oxygen Species - metabolism RNA Interference RNA, Messenger - metabolism Time Factors Transfection Vascular Remodeling - drug effects
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