G Protein-coupled Receptor Kinases of the GRK4 Protein Subfamily Phosphorylate Inactive G Protein-coupled Receptors (GPCRs)

G protein-coupled receptor (GPCR) kinases (GRKs) play a key role in homologous desensitization of GPCRs. It is widely assumed that most GRKs selectively phosphorylate only active GPCRs. Here, we show that although this seems to be the case for the GRK2/3 subfamily, GRK5/6 effectively phosphorylate i...

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Veröffentlicht in:	The Journal of biological chemistry 2015-04, Vol.290 (17), p.10775-10790
Hauptverfasser:	Li, Lingyong, Homan, Kristoff T., Vishnivetskiy, Sergey A., Manglik, Aashish, Tesmer, John J.G., Gurevich, Vsevolod V., Gurevich, Eugenia V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Adrenergic Receptor Animals Arrestin Arrestins - metabolism Cattle G Protein-coupled Receptor (GPCR) G Protein-coupled Receptor Kinase G-Protein-Coupled Receptor Kinase 4 - genetics G-Protein-Coupled Receptor Kinase 4 - metabolism G-Protein-Coupled Receptor Kinases - genetics G-Protein-Coupled Receptor Kinases - metabolism HEK293 Cells Humans Mutagenesis, Site-Directed Phosphorylation Receptors, G-Protein-Coupled - agonists Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Recombinant Proteins - genetics Recombinant Proteins - metabolism Rhodopsin Signal Transduction
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