FUS/TLS deficiency causes behavioral and pathological abnormalities distinct from amyotrophic lateral sclerosis

FUS/TLS is an RNA-binding protein whose genetic mutations or pathological inclusions are associated with neurological diseases including amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration, and essential tremor (ET). It is unclear whether their pathogenesis is mediated by gain or...

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Veröffentlicht in:	Acta neuropathologica communications 2015-04, Vol.3 (1), p.24-24, Article 24
Hauptverfasser:	Kino, Yoshihiro, Washizu, Chika, Kurosawa, Masaru, Yamada, Mizuki, Miyazaki, Haruko, Akagi, Takumi, Hashikawa, Tsutomu, Doi, Hiroshi, Takumi, Toru, Hicks, Geoffrey G, Hattori, Nobutaka, Shimogori, Tomomi, Nukina, Nobuyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - genetics Amyotrophic Lateral Sclerosis - physiopathology Animals Anxiety - psychology Behavior, Animal Brain Development and progression Disease Models, Animal Essential Tremor - genetics Essential Tremor - physiopathology Gene mutations Genetic aspects Health aspects Heterogeneous-Nuclear Ribonucleoprotein Group A-B - genetics Homozygote Hyperkinesis Mice Mice, Inbred C57BL Mice, Knockout Nervous system diseases Neurophysiology Phenotype Physiological aspects Protein binding RNA RNA-Binding Protein FUS - deficiency RNA-Binding Protein FUS - genetics RNA-Binding Proteins - genetics TATA-Binding Protein Associated Factors - genetics Tremor Up-Regulation
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