Molecular conformation of the full-length tumor suppressor NF2/Merlin--a small-angle neutron scattering study

The tumor suppressor protein Merlin inhibits cell proliferation upon establishing cell-cell contacts. Because Merlin has high level of sequence similarity to the Ezrin-Radixin-Moesin family of proteins, the structural model of Ezrin-Radixin-Moesin protein autoinhibition and cycling between closed/re...

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Veröffentlicht in:	Journal of molecular biology 2014-07, Vol.426 (15), p.2755-2768
Hauptverfasser:	Ali Khajeh, Jahan, Ju, Jeong Ho, Atchiba, Moussoubaou, Allaire, Marc, Stanley, Christopher, Heller, William T, Callaway, David J E, Bu, Zimei
Format:	Artikel
Sprache:	eng
Schlagworte:	Calorimetry Circular Dichroism Genes, Tumor Suppressor Humans Models, Molecular Molecular Conformation Neurofibromin 2 - chemistry Neurofibromin 2 - genetics Neurofibromin 2 - metabolism Neutron Diffraction - methods Phosphoproteins - metabolism Phosphorylation Scattering, Small Angle Sodium-Hydrogen Exchangers - metabolism Surface Plasmon Resonance
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