Diallyl trisulfide inhibits migration, invasion and angiogenesis of human colon cancer HT‐29 cells and umbilical vein endothelial cells, and suppresses murine xenograft tumour growth

Angiogenesis inhibitors are beneficial for the prevention and treatment of angiogenesis‐dependent diseases including cancer. We examined the cytotoxic, anti‐metastatic, anti‐cancer and anti‐angiogenic effects of diallyl trisulfide (DATS). In HT29 cells, DATS inhibited migration and invasion through...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2015-02, Vol.19 (2), p.474-484
Hauptverfasser:	Lai, Kuang‐Chi, Hsu, Shu‐Chun, Yang, Jai‐Sing, Yu, Chien‐Chih, Lein, Jin‐Cherng, Chung, Jing‐Gung
Format:	Artikel
Sprache:	eng
Schlagworte:	Allyl Compounds - pharmacology Angiogenesis Angiogenesis inhibitors Angiogenesis Inhibitors - pharmacology Animals Cancer therapies Capillary tubes Cell adhesion & migration Cell growth Cell Line Cell Line, Tumor Cell migration Cell Movement - drug effects Cell Proliferation - drug effects Chemotherapy Chorioallantoic membrane Colon cancer Colorectal cancer Crop diseases Cytokines Cytotoxicity DATS Diallyl trisulfide Endothelial cells Focal adhesion kinase Gene expression Growth factors Hemoglobin HT29 Cells HT‐29 human colon adenocarcinoma cells Human Umbilical Vein Endothelial Cells - drug effects Humans HUVEC Industrial research Inhibition JNK protein Kinases Matrix metalloproteinase Medical treatment Metastases Metastasis Mice migration and invasion Neoplasm Invasiveness - prevention & control Neovascularization, Pathologic - drug therapy Original Poultry Proteins R&D Research & development Secretion Sulfides - pharmacology Tumors Umbilical vein Vascular endothelial growth factor Veins Veins & arteries Xenograft Model Antitumor Assays - methods Xenografts
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