The role of the microbiota in ageing: current state and perspectives
Since the application of high‐throughput technologies to investigate complex microbial communities, alterations in the human gut microbiota have been associated with an increasing number of diseases and conditions. This field of research has developed into an area of intense study which is quite dif...
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| Veröffentlicht in: | Wiley interdisciplinary reviews. Mechanisms of disease 2015-05, Vol.7 (3), p.131-138 |
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| creator | Lynch, Denise B. Jeffery, Ian B. O'Toole, Paul W. |
| description | Since the application of high‐throughput technologies to investigate complex microbial communities, alterations in the human gut microbiota have been associated with an increasing number of diseases and conditions. This field of research has developed into an area of intense study which is quite different to the microbial investigations that have preceded it in terms of both the broadness of the area of research and the complexity of the analyses. In this review, we discuss gut microbiota changes observed in ageing in the context of the physiological changes that accompany senescence, examine what correlations can be established or inferred, and we discuss what key questions remain to be answered in the field. WIREs Syst Biol Med 2015, 7:131–138. doi: 10.1002/wsbm.1293
This article is categorized under:
Developmental Biology > Developmental Processes in Health and Disease
Physiology > Mammalian Physiology in Health and Disease |
| doi_str_mv | 10.1002/wsbm.1293 |
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This article is categorized under:
Developmental Biology > Developmental Processes in Health and Disease
Physiology > Mammalian Physiology in Health and Disease</description><identifier>ISSN: 1939-5094</identifier><identifier>EISSN: 1939-005X</identifier><identifier>EISSN: 2692-9368</identifier><identifier>DOI: 10.1002/wsbm.1293</identifier><identifier>PMID: 25777986</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Aging - physiology ; Complexity ; Developmental biology ; Focus ; Gastrointestinal Microbiome - physiology ; Gastrointestinal Tract - microbiology ; Gastrointestinal Tract - physiopathology ; Humans ; Intestinal microflora ; Microbial activity ; Microbiota ; Microorganisms ; Models, Biological ; Physiology ; Senescence</subject><ispartof>Wiley interdisciplinary reviews. Mechanisms of disease, 2015-05, Vol.7 (3), p.131-138</ispartof><rights>2015 The Authors. and Medicine published by Wiley Periodicals, Inc.</rights><rights>2015 The Authors. WIREs Systems Biology and Medicine published by Wiley Periodicals, Inc.</rights><rights>2015. This article is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 The Authors. published by Wiley Periodicals, Inc. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5143-7bb2c81ef2c60e441b688c0ab164c19f93d9802e8f98c2dd5bc62e679d124c5c3</citedby><cites>FETCH-LOGICAL-c5143-7bb2c81ef2c60e441b688c0ab164c19f93d9802e8f98c2dd5bc62e679d124c5c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fwsbm.1293$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fwsbm.1293$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25777986$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lynch, Denise B.</creatorcontrib><creatorcontrib>Jeffery, Ian B.</creatorcontrib><creatorcontrib>O'Toole, Paul W.</creatorcontrib><title>The role of the microbiota in ageing: current state and perspectives</title><title>Wiley interdisciplinary reviews. Mechanisms of disease</title><addtitle>WIREs Syst Biol Med</addtitle><description>Since the application of high‐throughput technologies to investigate complex microbial communities, alterations in the human gut microbiota have been associated with an increasing number of diseases and conditions. This field of research has developed into an area of intense study which is quite different to the microbial investigations that have preceded it in terms of both the broadness of the area of research and the complexity of the analyses. In this review, we discuss gut microbiota changes observed in ageing in the context of the physiological changes that accompany senescence, examine what correlations can be established or inferred, and we discuss what key questions remain to be answered in the field. WIREs Syst Biol Med 2015, 7:131–138. doi: 10.1002/wsbm.1293
This article is categorized under:
Developmental Biology > Developmental Processes in Health and Disease
Physiology > Mammalian Physiology in Health and Disease</description><subject>Aging - physiology</subject><subject>Complexity</subject><subject>Developmental biology</subject><subject>Focus</subject><subject>Gastrointestinal Microbiome - physiology</subject><subject>Gastrointestinal Tract - microbiology</subject><subject>Gastrointestinal Tract - physiopathology</subject><subject>Humans</subject><subject>Intestinal microflora</subject><subject>Microbial activity</subject><subject>Microbiota</subject><subject>Microorganisms</subject><subject>Models, Biological</subject><subject>Physiology</subject><subject>Senescence</subject><issn>1939-5094</issn><issn>1939-005X</issn><issn>2692-9368</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQhi0EoqXlwB9AkbjAIa3t-JNDJbrQlmoLB4rKzXKcydYliRc7aem_r1e7rAAJiZNH8jOPZuZF6AXBBwRjeniX6v6AUF09QrtEV7rEmH97vKk51mwHPUvpBmPBmdZP0Q7lUkqtxC56f3kNRQwdFKEtxlz33sVQ-zDawg-FXYAfFm8LN8UIw1ik0Y5Q2KEplhDTEtzobyHtoyet7RI837x76OvJh8vZWTn_fPpx9m5eOk5YVcq6pk4RaKkTGBgjtVDKYVsTwRzRra4arTAF1WrlaNPw2gkKQuqGUOa4q_bQ0dq7nOoeGpcnirYzy-h7G-9NsN78-TP4a7MIt4YxLEilsuD1RhDDjwnSaHqfHHSdHSBMyRChmVaUCvEfqKQCc8lkRl_9hd6EKQ75EobmeCopscCZerOm8n1TitBu5ybYrGI0qxjNKsbMvvx90S35K7cMHK6BO9_B_b9N5urL8cVGWa47fBrh57bDxu9GyEpyc_Xp1MzOxfHsnJ6ZefUAyPi2VQ</recordid><startdate>201505</startdate><enddate>201505</enddate><creator>Lynch, Denise B.</creator><creator>Jeffery, Ian B.</creator><creator>O'Toole, Paul W.</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><scope>7T7</scope><scope>C1K</scope><scope>5PM</scope></search><sort><creationdate>201505</creationdate><title>The role of the microbiota in ageing: current state and perspectives</title><author>Lynch, Denise B. ; Jeffery, Ian B. ; O'Toole, Paul W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5143-7bb2c81ef2c60e441b688c0ab164c19f93d9802e8f98c2dd5bc62e679d124c5c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aging - physiology</topic><topic>Complexity</topic><topic>Developmental biology</topic><topic>Focus</topic><topic>Gastrointestinal Microbiome - physiology</topic><topic>Gastrointestinal Tract - microbiology</topic><topic>Gastrointestinal Tract - physiopathology</topic><topic>Humans</topic><topic>Intestinal microflora</topic><topic>Microbial activity</topic><topic>Microbiota</topic><topic>Microorganisms</topic><topic>Models, Biological</topic><topic>Physiology</topic><topic>Senescence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lynch, Denise B.</creatorcontrib><creatorcontrib>Jeffery, Ian B.</creatorcontrib><creatorcontrib>O'Toole, Paul W.</creatorcontrib><collection>Istex</collection><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Wiley interdisciplinary reviews. Mechanisms of disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lynch, Denise B.</au><au>Jeffery, Ian B.</au><au>O'Toole, Paul W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of the microbiota in ageing: current state and perspectives</atitle><jtitle>Wiley interdisciplinary reviews. Mechanisms of disease</jtitle><addtitle>WIREs Syst Biol Med</addtitle><date>2015-05</date><risdate>2015</risdate><volume>7</volume><issue>3</issue><spage>131</spage><epage>138</epage><pages>131-138</pages><issn>1939-5094</issn><eissn>1939-005X</eissn><eissn>2692-9368</eissn><abstract>Since the application of high‐throughput technologies to investigate complex microbial communities, alterations in the human gut microbiota have been associated with an increasing number of diseases and conditions. This field of research has developed into an area of intense study which is quite different to the microbial investigations that have preceded it in terms of both the broadness of the area of research and the complexity of the analyses. In this review, we discuss gut microbiota changes observed in ageing in the context of the physiological changes that accompany senescence, examine what correlations can be established or inferred, and we discuss what key questions remain to be answered in the field. WIREs Syst Biol Med 2015, 7:131–138. doi: 10.1002/wsbm.1293
This article is categorized under:
Developmental Biology > Developmental Processes in Health and Disease
Physiology > Mammalian Physiology in Health and Disease</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>25777986</pmid><doi>10.1002/wsbm.1293</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1939-5094 |
| ispartof | Wiley interdisciplinary reviews. Mechanisms of disease, 2015-05, Vol.7 (3), p.131-138 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aging - physiology Complexity Developmental biology Focus Gastrointestinal Microbiome - physiology Gastrointestinal Tract - microbiology Gastrointestinal Tract - physiopathology Humans Intestinal microflora Microbial activity Microbiota Microorganisms Models, Biological Physiology Senescence |
| title | The role of the microbiota in ageing: current state and perspectives |
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